TRIM25 promotes oncogenic activities through regulation of ZEB1 in breast cancer

被引：0
作者：
Cao, Fei [1 ]
Li, Da-Peng [1 ]
Wang, Lei [2 ]
Li, Min [3 ]
Zhang, Hui [4 ]
Tao, Min [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Dept Oncol, Suzhou, Jiangsu, Peoples R China
[2] Northern Dist Suzhou Municipal Hosp, Dept Gen Surg, Suzhou, Jiangsu, Peoples R China
[3] Northern Dist Suzhou Municipal Hosp, Dept Pathol, Suzhou, Jiangsu, Peoples R China
[4] Northern Dist Suzhou Municipal Hosp, Dept Oncol, 188 Shizi Rd, Suzhou 215006, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2016年 / 9卷 / 10期
基金：
美国国家科学基金会;
关键词：
TRIM25; breast cancer; ZEB-1; EMT; RIG-I; UBIQUITIN LIGASE; CUL4A; RNA; CELLS; STATISTICS; EXPRESSION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tripartite motif 25 (TRIM25) is a kind of E3 ligase of ubiquitin-proteasome pathway. It was found to act in immunologic response, regulation and control of mitotic cycle and tumor cell's drug resistance. In this study, we found that TRIM25 was increased in breast cancer. Knockdown of TRIM25 inhibited the migration, invasion and epithelial-mesenchymal transitions (EMT) of breast cancer cells. Meanwhile, over-expression of TRIM25 promoted the migration, invasion and EMT of breast cancer cells. Western blot analysis indicated that ZEB-1 may play function as a downstream factor of TRIM25. Knockdown of TRIM25 can inhibit ZEB-1's expression. And interference of ZEB-1 can also inhibited the cell's ability of migration, invasion and EMT; even in a cell line who's TRIM25 was over expressed. Together, these results helped to realize the oncogene functions of TRIM25 in breast cancer cells, and provided a novel direction to treat breast cancer.
引用
收藏
页码：9751 / 9760
页数：10
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