Salvage radiotherapy after radical prostatectomy: outcomes and prognostic factors especially focusing on pathological findings

被引:8
作者
Hayashi, Satoko [1 ]
Hayashi, Keiji [1 ]
Yoshimura, Ryo-ichi [1 ]
Masuda, Hitoshi [2 ]
Kihara, Kazunori [2 ]
Shibuya, Hitoshi [1 ]
机构
[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Radiat Oncol, Tokyo 1138519, Japan
[2] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Urol, Tokyo 1138519, Japan
关键词
prostatectomy; salvage radiotherapy; prostate cancer; prostate-specific antigen; pathological findings; LYMPHOVASCULAR INVASION; RADIATION-THERAPY; ANTIGEN LEVELS; CANCER; RECURRENCE; DISEASE; ELEVATION;
D O I
10.1093/jrr/rrs034
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
External beam radiotherapy is a potential salvage or adjuvant therapy after radical prostatectomy (RP). The purpose of this study was to investigate the treatment outcome of salvage radiotherapy (RT) following RP for clinically localized prostate cancer and to identify factors that may predict the outcome of salvage RT. Between 2000 and 2006, 41 patients received salvage RT because of increasing prostate-specific antigen (PSA) levels following an RP for clinically localized prostate cancer. All the patients received conformal radiotherapy to the prostate bed. The prescribed radiation dose was 60-70 Gy in 26-35 fractions. The overall 5-year biochemical disease-free survival rate was 38%. A multivariate analysis showed that the following pathological findings of the surgical specimen were significantly associated with biochemical failure following salvage RT: a high Gleason score, a negative surgical margin, seminal vesicle invasion, lymphatic vessel invasion and negative vascular invasion. Among these factors, lymphatic vessel invasion was the strongest predictor. in conclusion, the pathological features affected the outcome of salvage RT following RP. Lymphatic vessel invasion was strongly associated with the risk of biochemical failure despite salvage RT. Meanwhile, vascular invasion was not a significant hazardous factor.
引用
收藏
页码:727 / 734
页数:8
相关论文
共 21 条
  • [1] Radiotherapy for a rising prostate-specific antigen after radical prostatectomy: The first 10 years
    Anscher, MS
    Clough, R
    Dodge, R
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2000, 48 (02): : 369 - 375
  • [2] INCIDENCE AND PROGNOSTIC-SIGNIFICANCE OF LYMPHATIC AND VASCULAR INVASION IN RADICAL PROSTATECTOMY SPECIMENS
    BAHNSON, RR
    DRESNER, SM
    GOODING, W
    BECICH, MJ
    [J]. PROSTATE, 1989, 15 (02) : 149 - 155
  • [3] Lymphovascular invasion in prostate cancer - Prognostic significance in patients treated with radiotherapy after radical prostatectomy
    Brooks, JP
    Albert, PS
    O'Connell, J
    McLeod, DG
    Poggi, MM
    [J]. CANCER, 2006, 106 (07) : 1521 - 1526
  • [4] Impact of Postoperative Prostate-Specific Antigen Disease Recurrence and the Use of Salvage Therapy on the Risk of Death
    Choueiri, Toni K.
    Chen, Ming-Hui
    D'Amico, Anthony V.
    Sun, Leon
    Nguyen, Paul L.
    Hayes, Julia H.
    Robertson, Cary N.
    Walther, Philip J.
    Polascik, Thomas J.
    Albala, David M.
    Moul, Judd W.
    [J]. CANCER, 2010, 116 (08) : 1887 - 1892
  • [5] Cox JD, 1999, J CLIN ONCOL, V17, P1155
  • [6] OUTCOME AFTER CONFORMAL SALVAGE RADIOTHERAPY IN PATIENTS WITH RISING PROSTATE-SPECIFIC ANTIGEN LEVELS AFTER RADICAL PROSTATECTOMY
    Geinitz, Hans
    Riegel, Martina G.
    Thamm, Reinhard
    Astner, Sabrina T.
    Lewerenz, Carolin
    Zimmermann, Frank
    Molls, Michael
    Nieder, Carsten
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (05): : 1930 - 1937
  • [7] Cancer statistics, 2006
    Jemal, A
    Siegel, R
    Ward, E
    Murray, T
    Xu, JQ
    Smigal, C
    Thun, MJ
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2006, 56 (02) : 106 - 130
  • [8] Minimum Incision Endoscopic Surgery (MIES) in Japanese Urology: Results of Adrenalectomy, Radical Nephrectomy and Radical Prostatectomy
    Kihara, K.
    Kobayashi, T.
    Kawakami, S.
    Fujii, Y.
    Kageyama, Y.
    Masuda, H.
    [J]. AKTUELLE UROLOGIE, 2010, 41 : S15 - S19
  • [9] Prediction of response to salvage radiation therapy in patients with prostrate cancer recurrence after radical prostatectomy
    Leventis, AK
    Shariat, SF
    Kattan, MW
    Butler, EB
    Wheeler, TM
    Slawin, KM
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (04) : 1030 - 1039
  • [10] Salvage radiotherapy for biochemical failure of radical prostatectomy: A single-institution experience
    Liauw, SL
    Webster, WS
    Pistenmaa, DA
    Roehrborn, CG
    [J]. UROLOGY, 2003, 61 (06) : 1204 - 1210