Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

被引：56

作者：

Chen, Po-Jung ^{[1
]}

Kang, Yi-Da ^{[1
]}

Lin, Chen-Huan ^{[2
,3
]}

Chen, San-Yuan ^{[1
]}

Hsieh, Chia-Hung ^{[4
]}

Chen, You-Yin ^{[5
]}

Chiang, Chun-Wei ^{[2
,3
]}

Lee, Wei ^{[2
,3
]}

Hsu, Chung-Y ^{[6
]}

Liao, Lun-De ^{[7
,8
]}

Fan, Chih-Tai ^{[9
]}

Li, Meng-Lin ^{[9
,10
]}

Shyu, Woei-Cherng ^{[2
,3
,11
]}

机构：

[1] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 300, Taiwan

[2] China Med Univ & Hosp, Ctr Neuropsychiat, Taichung 40447, Taiwan

[3] China Med Univ & Hosp, Dept Neurol, Taichung 40447, Taiwan

[4] China Med Univ, Grad Inst Basic Med Sci, Taichung 40402, Taiwan

[5] Natl Yang Ming Univ, Dept Biomed Engn, Taipei 112, Taiwan

[6] China Med Univ, Grad Inst Clin Med Sci, Taichung 40402, Taiwan

[7] Natl Univ Singapore, Singapore Inst Neurotechnol SINAPSE, Singapore 117548, Singapore

[8] Natl Hlth Res Inst, Inst Biomed Engn & Nanomed, Zhunan Town 35053, Miaoli County, Taiwan

[9] Natl Tsing Hua Univ, Dept Elect Engn, Hsinchu 30013, Taiwan

[10] Natl Tsing Hua Univ, Inst Photon Technol, Hsinchu 30013, Taiwan

[11] China Med Univ, Grad Inst Immunol, Taichung 40402, Taiwan

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 41期

关键词：

CEREBRAL-ISCHEMIA; DIFFERENTIATION; TRANSPLANTATION; NEUROPLASTICITY; NANOPARTICLES; MIGRATION;

D O I：

10.1002/adma.201502784

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote-controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long-term monitoring to achieve therapeutic efficacy.

引用

页码：6488 / +

页数：9

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