An efficient synthesis of isoquinolines via rhodium-catalyzed direct C-H functionalization of arylhydrazines

被引：39

作者：

Zhang, Sai ^{[1
,2
]}

Huang, Daorui ^{[1
]}

Xu, Guangyang ^{[1
]}

Cao, Shengyu ^{[1
]}

Wang, Rong ^{[1
]}

Peng, Shiyong ^{[1
]}

Sun, Jiangtao ^{[1
]}

机构：

[1] Changzhou Univ, Sch Pharmaceut Engn & Life Sci, Changzhou 213164, Peoples R China

[2] St Francis Xavier Univ, Dept Chem, Antigonish, NS B2G 2W5, Canada

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 29期

基金：

中国国家自然科学基金;

关键词：

O-METHYLBENZOHYDROXIMOYL HALIDES; ONE-POT SYNTHESIS; BOND ACTIVATION; COUPLING REACTIONS; N-OXIDES; CYCLIZATION; PYRIDINES; ALKYNES; ROUTE; OXIMES;

D O I：

10.1039/c5ob01171j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient rhodium-catalyzed C-H activation of arylhydrazines and coupling with internal alkynes has been realized under mild conditions. The isoquinolines have been prepared in moderate to excellent yields in high efficiency. This methodology features the use of readily available starting materials, and a simple hydrazine moiety as a directing group, in the absence of an external metal co-oxidant under an air atmosphere. The C-H bond activation and the N-N bond cleavage have been successively realized under mild conditions.

引用

页码：7920 / 7923

页数：4