Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells

被引：152

作者：

Perez, Marcos A. ^{[1
,2
]}

Magtanong, Leslie ^{[3
]}

Dixon, Scott J. ^{[3
]}

Watts, Jennifer L. ^{[1
,2
]}

机构：

[1] Washington State Univ, Sch Mol Biosci, Pullman, WA 99164 USA

[2] Washington State Univ, Ctr Reprod Biol, Pullman, WA 99164 USA

[3] Stanford Univ, Dept Biol, Stanford, CA USA

来源：

DEVELOPMENTAL CELL | 2020年 / 54卷 / 04期

关键词：

OXIDATIVE STRESS; DEATH; PEROXIDATION; PLASMALOGENS; MANIPULATION; METABOLISM; DISEASE;

D O I：

10.1016/j.devcel.2020.06.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dietary lipids impact development, homeostasis, and disease, but links between specific dietary fats and cell fates are poorly understood. Ferroptosis is an iron-dependent form of nonapoptotic cell death associated with oxidized polyunsaturated phospholipids. Here, we show that dietary ingestion of the polyunsaturated fatty acid (PUFA) dihomogamma-linolenic acid (DGLA; 20:3n-6) can trigger germ-cell ferroptosis and sterility in the nematode Caenorhabditis elegans. Exogenous DGLA is also sufficient to induce ferroptosis in human cells, pinpointing this omega-6 PUFA as a conserved metabolic instigator of this lethal process. In both C. elegans and human cancer cells, ether-lipid synthesis protects against ferroptosis. These results establish C. elegans as a powerful animal model to study the induction and modulation of ferroptosis by dietary fats and indicate that endogenous ether lipids act to prevent this nonapoptotic cell fate.

引用

页码：447 / +

页数：12

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