Synthesis and study of 2-acetyl amino-3-[4-(2-amino-5-sulfo-phenylazo)-phenyl]-propionic acid: a new class of inhibitor for hen egg white lysozyme amyloidogenesis

被引：13

作者：

Maity, Sibaprasad ^{[1
]}

Kumar, Ravi ^{[1
]}

Maity, Suman Kumar ^{[1
]}

Jana, Poulami ^{[1
]}

Bera, Santu ^{[1
]}

Haldar, Debasish ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741252, W Bengal, India

来源：

MEDCHEMCOMM | 2013年 / 4卷 / 03期

关键词：

AMYLOID FIBRIL FORMATION; CONGO RED; TAU AGGREGATION; PROTEIN; DISEASE; FLUORESCENCE; DERIVATIVES; SHEET; SPECTROSCOPY; OLIGOMERS;

D O I：

10.1039/c2md20236k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The compounds capable of blocking the aggregation of amyloidogenic proteins may have therapeutic potentials. We report on the synthesis of 2-acetyl amino-3-[4-(2-amino-5-sulfo-phenylazo)-phenyl]propionic acid as an HEWL (hen egg white lysozyme) amyloid inhibitor starting from phenylalanine. The compounds arrest the monomers and exhibit anti-aggregating activity. Moreover, the acetyl derivative 1 served as a better inhibitor than the trifluoroacetyl derivative 2 against in vitro amyloid fibrillogenesis of the HEWL model system.

引用

收藏

页码：530 / 536

页数：7

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