Novel Positron Emission Tomography Tracers for Imaging Vascular Inflammation

被引：21

作者：

Corovic, Andrej ^{[1
]}

Wall, Christopher ^{[1
]}

Mason, Justin C. ^{[2
]}

Rudd, James H. F. ^{[1
]}

Tarkin, Jason M. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Div Cardiovasc Med, Cambridge, England

[2] Imperial Coll London, Natl Heart & Lung Inst, Cardiovasc Div, London, England

来源：

CURRENT CARDIOLOGY REPORTS | 2020年 / 22卷 / 10期

基金：

英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

PET; Inflammation; Atherosclerosis; Large-vessel vasculitis; Molecular imaging; Non-invasive imaging; ATHEROSCLEROTIC PLAQUE INFLAMMATION; LARGE VESSEL VASCULITIS; RECEPTOR; 4; EXPRESSION; TARGETING P-SELECTIN; RISK-FACTORS; NONINVASIVE ASSESSMENT; IMPROVES PREDICTION; FDG UPTAKE; PET; GA-68-PENTIXAFOR;

D O I：

10.1007/s11886-020-01372-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of ReviewTo provide a focused update on recent advances in positron emission tomography (PET) imaging in vascular inflammatory diseases and consider future directions in the field.Recent FindingsWhile PET imaging with F-18-fluorodeoxyglucose (FDG) can provide a useful marker of disease activity in several vascular inflammatory diseases, including atherosclerosis and large-vessel vasculitis, this tracer lacks inflammatory cell specificity and is not a practical solution for imaging the coronary vasculature because of avid background myocardial signal. To overcome these limitations, research is ongoing to identify novel PET tracers that can more accurately track individual components of vascular immune responses. Use of these novel PET tracers could lead to a better understanding of underlying disease mechanisms and help inform the identification and stratification of patients for newly emerging immune-modulatory therapies.SummaryFuture research is needed to realise the true clinical translational value of PET imaging in vascular inflammatory diseases.

引用

页数：11

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