AreKIF6andAPOEpolymorphisms associated with power and endurance athletes?

被引：5

作者：

Wojciechowicz, Bartosz ^{[1
]}

Laguette, M. -J. Nancy ^{[2
,3
,4
]}

Sawczuk, Marek ^{[1
]}

Huminska-Lisowska, Kinga ^{[1
]}

Maciejewska-Skrendo, Agnieszka ^{[1
]}

Ficek, Krzysztof ^{[5
]}

Michalowska-Sawczyn, Monika ^{[1
]}

Leonska-Duniec, Agata ^{[1
]}

Kaczmarczyk, Mariusz ^{[6
]}

Chycki, Jakub ^{[7
]}

Trybek, Grzegorz ^{[8
]}

September, Alison V. ^{[2
,3
,4
]}

Cieszczyk, Pawel ^{[1
]}

机构：

[1] Gdansk Univ Phys Educ & Sport, Fac Phys Educ, Gdansk, Poland

[2] Univ Cape Town, Hlth Sci Fac, Human Biol Dept, Div Exercise Sci & Sports Med ESSM, Cape Town, South Africa

[3] Univ Cape Town, Collaborat Ctr Sports Med, ESSM, Int Federat Sports Med FIMS, Cape Town, South Africa

[4] Univ Cape Town, Res Ctr Hlth Phys Act & Sport, Cape Town, South Africa

[5] Acad Phys Educ Katowice, Fac Physiotherapy, Katowice, Poland

[6] West Pomeranian Univ Technol Szczecin, Phys Educ Dept, Szczecin, Poland

[7] Acad Phys Educ Katowice, Fac Phys Educ, Katowice, Poland

[8] Pomeranian Med Univ, Dept Oral Surg, Szczecin, Poland

来源：

EUROPEAN JOURNAL OF SPORT SCIENCE | 2021年 / 21卷 / 09期

关键词：

Kinesin family member 6; apolipoprotein E; athletic performance; genetic association; PERFORMANCE; GENE;

D O I：

10.1080/17461391.2020.1817983

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

Genetic polymorphisms within physiologically relevantKIF6andAPOEgenes were examined in the context of athletic performance. KIF6 and ApoE are involved in cardiovascular health, modulation of lipid level and neurotransmission amongst others. The aim of this study was to examine whether three polymorphisms,KIF6rs20455T > C,APOErs429358T > C andAPOErs7412 C > T, were associated with athletic status of an athlete defined as performance type (endurance or power). Genotyping was performed using real-time PCR on buccal genomic DNA from 204 Polish athletes including 104 endurance and 100 power athletes, and 161 sedentary individuals.APOErs429358 genotype frequencies differed significantly between power athletes and sedentary individuals (p = 0.046).KIF6rs20455 andAPOErs7412 were found to be epistatically associated with the power athletic status (p = 0.032).KIF6rs20455,APOErs429358 andAPOErs7412 were associated with athletic status of Polish athletes. In the future, these polymorphisms could contribute to predictive models aimed at assessment of an individual's athletic status.

引用

页码：1283 / 1289

页数：7

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