Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population:: The Nord-Trondelag Health Study (HUNT)

Background: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. The aim of the present study was to examine the relationship between the Val158Met COMT gene polymorphism and anxiety and depression measured by the Hospital Anxiety and Depression Scale (HADS) in the general adult population. Methods: In the Nord-Trondelag Health Study (HUNT) the association between the Val158Met polymorphism and anxiety and depression was evaluated in a random sample of 5531 individuals. Two different cut off scores (>= 8 and >= 11) were used to identify cases with anxiety (HADS-A) and depression (HADS-D), whereas controls had HADS-A < 8 and HADS-D < 8. Results: The COMT genotype distribution was similar between controls and individuals in the groups with anxiety and depression using cut-off scores of >= 8. When utilizing the alternative cutoff score HADS-D >= 11, Met/Met genotype and Met allele were less common among men with depression compared to the controls (genotype: p = 0.017, allele: p = 0.006). In the multivariate analysis, adjusting for age and heart disease, depression (HADS-D >= 11) was less likely among men with the Met/Met genotype than among men with the Val/Val genotype (OR = 0.37, 95% CI = 0.18-0.76). Conclusion: In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. The Met/Met genotype was less likely among men with depression defined as HADS-D >= 11, but this may be an incidental finding.