Protein kinase Cβ and δ selectively phosphorylate odorant and metabotropic glutamate receptors

被引：6

作者：

Medler, KF ^{[1
]}

Bruch, RC ^{[1
]}

机构：

[1] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA

来源：

CHEMICAL SENSES | 1999年 / 24卷 / 03期

关键词：

D O I：

10.1093/chemse/24.3.295

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Recombinant protein segments from a metabotropic glutamate receptor and from an odorant receptor were used as substrates in protein kinase C phosphorylation assays. Protein kinase C beta and delta phosphorylated an intracellular consensus phosphorylation site in the metabotropic glutamate receptor. Only protein kinase C delta phosphorylated a novel extracellular consensus phosphorylation site in the odorant receptor. These results suggest differential regulation of these receptors by protein kinase C isotypes.

引用

页码：295 / 299

页数：5

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