Protein kinase Cβ and δ selectively phosphorylate odorant and metabotropic glutamate receptors

被引：6
|
作者：
Medler, KF [1 ]
Bruch, RC [1 ]
机构：
[1] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA
来源：
CHEMICAL SENSES | 1999年 / 24卷 / 03期
关键词：
D O I：
10.1093/chemse/24.3.295
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Recombinant protein segments from a metabotropic glutamate receptor and from an odorant receptor were used as substrates in protein kinase C phosphorylation assays. Protein kinase C beta and delta phosphorylated an intracellular consensus phosphorylation site in the metabotropic glutamate receptor. Only protein kinase C delta phosphorylated a novel extracellular consensus phosphorylation site in the odorant receptor. These results suggest differential regulation of these receptors by protein kinase C isotypes.
引用
收藏
页码：295 / 299
页数：5
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