Diagnosis and prediction of parental origin of triploidies by fetal nuchal translucency and maternal serum free β-hCG and PAPP-A at 11-14 weeks of gestation

被引：8

作者：

Barken, Sidsel S. ^{[1
,2
]}

Skibsted, Lillian ^{[1
,3
]}

Jensen, Lisa N. ^{[4
]}

Sperling, Lene ^{[5
]}

Zingenberg, Helle ^{[6
]}

Brondum-Nielsen, Karen ^{[2
,3
]}

机构：

[1] Roskilde Sygehus, Dept Obstet & Gynecol, Roskilde, Denmark

[2] Kennedy Ctr, Glostrup, Denmark

[3] Univ Copenhagen, Fac Hlth, DK-1168 Copenhagen, Denmark

[4] Gentofte Univ Hosp, Dept Obstet & Gynecol, Hellerup, Denmark

[5] Glostrup Cty Hosp, Dept Obstet & Gynecol, Glostrup, Denmark

[6] Herlev Hosp, Dept Obstet & Gynecol, Herlev, Denmark

来源：

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA | 2008年 / 87卷 / 09期

关键词：

triploidy; parental origin; first-trimester screening; nuchal translucency; maternal serum free beta-hCG; PAPP-A;

D O I：

10.1080/00016340802275927

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The study objective was to determine the parental origin of triploidy in relation to findings from early risk assessment in a combined screening program between 2004 and the end of 2006. Triploidy was diagnosed in six chorion villus samples and two samples from missed abortions. After informed consent, quantitative fluorescence polymerase chain reaction analysis was performed on the five cases where we received blood from both parents and tissue from fetuses. In four cases the origin of the triploidy was paternal and in one maternal, in accordance with previous findings in type I and type II triploidies. Finding triploidy is possible by risk assessment (ultrasound and double test), and thereby women may have the opportunity for early termination of pregnancy.

引用

页码：975 / 978

页数：4

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