Stability and compatibility study on enalapril maleate using thermoanalytical techniques

被引：27
|
作者：
Rezende, R. L. O. [2 ]
Santoro, M. I. R. M. [2 ]
Matos, J. R. [1 ]
机构：
[1] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, BR-05508 Sao Paulo, Brazil
[2] Univ Sao Paulo, Coll Pharmaceut Sci, Dept Pharm, BR-05508 Sao Paulo, Brazil
来源：
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2008年 / 93卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
compatibility; DSC; enalapril maleate; stability; TG; thermal stabilization;
D O I：
10.1007/s10973-007-8187-4
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
This paper demonstrates the application of thermal analysis in compatibility and stability studies between it ACE inhibitor (enalapril maleate) and excipients. The results have helped to elucidate the reason of a stability problem observed (luring the storage of enalapril maleate tablets. Incompatibility between enalapril maleate and colloidal silicon dioxide was detected. Besides, it was confirmed that the reaction between enalapril maleate and NaHCO3 increases the thermal stability of the drug. This Study Supports the importance of using thermoanalytical methods in the development of pharmaceuticals.
引用
收藏
页码：881 / 886
页数：6
相关论文
共 50 条
  • [21] Thermal stability of dried apricots followed by thermoanalytical techniques
    Ostojic, S.
    Pezo, L.
    Kicanovic, M.
    Zlatanovic, S.
    Randjelovic, D.
    Gvozdenovic, J.
    Simonovic, B.
    ANNALS OF NUTRITION AND METABOLISM, 2011, 58 : 106 - 106
  • [22] Drug-excipient compatibility screening-Role of thermoanalytical and spectroscopic techniques
    Chadha, Renu
    Bhandari, Swati
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 87 : 82 - 97
  • [23] CHEMICAL STABILITY OF ENALAPRIL MALEATE DRUG SUBSTANCE AND TABLETS BY A STABILITY-INDICATING LIQUID CHROMATOGRAPHIC METHOD
    de Diego, Marta
    Godoy, Gloria
    Mennickent, Sigrid
    Godoy, Ricardo
    QUIMICA NOVA, 2011, 34 (03): : 450 - 454
  • [24] Fluidized Bed Hot Melt Granulation with Hydrophilic Materials Improves Enalapril Maleate Stability
    Thiago F. Guimarães
    Amanda C. C. Comelli
    Luciana A. Tacón
    Talita A. Cunha
    Ricardo N. Marreto
    Luís A. P. Freitas
    AAPS PharmSciTech, 2017, 18 : 1302 - 1310
  • [25] Determination of Enalapril maleate from tablets using a new HPLC method
    Gherman, Simona
    Zavastin, Daniela
    Spac, Adrian
    Panainte, Alina Diana
    OVIDIUS UNIVERSITY ANNALS OF CHEMISTRY, 2021, 32 (01) : 70 - 75
  • [26] Fluidized Bed Hot Melt Granulation with Hydrophilic Materials Improves Enalapril Maleate Stability
    Guimaraes, Thiago F.
    Comelli, Amanda C. C.
    Tacon, Luciana A.
    Cunha, Talita A.
    Marreto, Ricardo N.
    Freitas, Luis A. P.
    AAPS PHARMSCITECH, 2017, 18 (04): : 1302 - 1310
  • [27] Study on the Mechanism Responsible for the Incompatibility of Enalapril Maleate with Sodium Starch Glycolate
    Bout, Merel Rachel
    Vromans, Herman
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 110 (05) : 2074 - 2082
  • [28] Determination and Degradation Study of Enalapril Maleate by High Performance Liquid Chromatography
    Sondes Bouabdallah
    Hassen Trabelsi
    M. R. Driss
    S. Touil
    Pharmaceutical Chemistry Journal, 2017, 51 : 735 - 741
  • [29] Determination and Degradation Study of Enalapril Maleate by High Performance Liquid Chromatography
    Bouabdallah, Sondes
    Trabelsi, Hassen
    Driss, M. R.
    Touil, S.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2017, 51 (08) : 735 - 741
  • [30] Characterisation of Polyurethane Coatings Using Thermoanalytical Techniques
    M. Ginic-Markovic
    N. R. Choudhury
    J. G. Matisons
    D. R. G. Williams
    Journal of Thermal Analysis and Calorimetry, 2000, 59 : 409 - 424
12345