Stability and compatibility study on enalapril maleate using thermoanalytical techniques

被引：27
|
作者：
Rezende, R. L. O. [2 ]
Santoro, M. I. R. M. [2 ]
Matos, J. R. [1 ]
机构：
[1] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, BR-05508 Sao Paulo, Brazil
[2] Univ Sao Paulo, Coll Pharmaceut Sci, Dept Pharm, BR-05508 Sao Paulo, Brazil
来源：
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2008年 / 93卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
compatibility; DSC; enalapril maleate; stability; TG; thermal stabilization;
D O I：
10.1007/s10973-007-8187-4
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
This paper demonstrates the application of thermal analysis in compatibility and stability studies between it ACE inhibitor (enalapril maleate) and excipients. The results have helped to elucidate the reason of a stability problem observed (luring the storage of enalapril maleate tablets. Incompatibility between enalapril maleate and colloidal silicon dioxide was detected. Besides, it was confirmed that the reaction between enalapril maleate and NaHCO3 increases the thermal stability of the drug. This Study Supports the importance of using thermoanalytical methods in the development of pharmaceuticals.
引用
收藏
页码：881 / 886
页数：6
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