The apicoplast as an antimalarial drug target

被引：142

作者：

Ralph, SA ^{[1
]}

D'Ombrain, MC ^{[1
]}

McFadden, GI ^{[1
]}

机构：

[1] Univ Melbourne, Sch Bot, Plant Cell Biol Res Ctr, Parkville, Vic 3010, Australia

来源：

DRUG RESISTANCE UPDATES | 2001年 / 4卷 / 03期

关键词：

D O I：

10.1054/drup.2001.0205

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Resistance to commonly used malaria drugs is spreading and new drugs are required urgently. The recent identification of a relict chloroplast (apicoplast) in malaria and related parasites offers numerous new targets for drug therapy using well-characterized compounds. The apicoplast contains a range of metabolic pathways and housekeeping processes that differ radically to those of the host thereby presenting ideal strategies for drug therapy. Indeed, many compounds targeting these plastid pathways are antimalarial and have favourable profiles based on extensive knowledge from their use as antibacterials. (C) 2001 Harcourt Publishers Ltd.

引用

页码：145 / 151

页数：7

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