Antimicrobial resistance of Actinobacillus pleuropneumoniae isolated from swine

被引：49

作者：

Vanni, Michele ^{[1
]}

Merenda, Marianna ^{[2
]}

Barigazzi, Giuseppe ^{[2
]}

Garbarino, Chiara ^{[3
]}

Luppi, Andrea ^{[4
]}

Tognetti, Rosalba ^{[1
]}

Intorre, Luigi ^{[1
]}

机构：

[1] Univ Pisa, Dept Vet Clin, Sect Vet Pharmacol & Toxicol, Fac Vet Med, I-56122 Pisa, Italy

[2] Ist Zooprofilatt Sperimentale Lombardia & Emilia, Diagnost Sect Parma, Parma, Italy

[3] Ist Zooprofilatt Sperimentale Lombardia & Emilia, Diagnost Sect Piacenza, Piacenza, Italy

[4] Ist Zooprofilatt Sperimentale Lombardia & Emilia, Diagnost Sect Reggio Emilia, Reggio Emilia, Italy

来源：

VETERINARY MICROBIOLOGY | 2012年 / 156卷 / 1-2期

关键词：

Actinobacillus pleuropneumoniae; Swine; Antimicrobial resistance; Trend; Italy; SUSCEPTIBILITY; PIGS; FLORFENICOL; BOVINE; PATHOGENS; BACTERIA; VACCINES; STRAINS;

D O I：

10.1016/j.vetmic.2011.10.022

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The aim of this retrospective study was to evaluate the antimicrobial resistance rates and the trend in resistance of Actinobacillus pleuropneumoniae isolated from pigs in Italy from 1994 to 2009. A total of 992 A. pleuropneumoniae isolates were tested for their susceptibility to a panel of antimicrobial agents in a disk diffusion method. Resistance to 7 drugs (amoxicillin, amoxicillin/clavulanic acid, ampicillin, cefquinome, cotrimoxazole, penicillin G and tilmicosin) showed a significant increasing trend over the time, while for 2 drugs (gentamycin and marbofloxacin) a significant decrease was observed. Resistance to the remaining 14 antimicrobial agents tested did not change significantly over the study period. Most of the isolates retained high susceptibility to antimicrobials usually effective against A. pleuropneumoniae such as amphenicols, fluoroquinolones and ceftiofur. However, high rates of resistance were observed for potentiated sulfa drugs, tetracyclines and penicillins which are currently recommended antimicrobials for pig pleuropneumonia therapy. Our results suggest the importance of continued monitoring of A. pleuropneumoniae clinical isolates in order to choose the most appropriate treatment of infections and to control the increase of resistance to currently used antimicrobials. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：172 / 177

页数：6

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