Ruthenium(II)-Catalyzed Traceless C-H Functionalization Using an N-N Bond as an Internal Oxidant

被引：24

作者：

Zhou, Shuguang ^{[1
]}

Wang, Jinhu ^{[1
]}

Chen, Pei ^{[1
]}

Chen, Kehao ^{[1
]}

Zhu, Jin ^{[1
]}

机构：

[1] Nanjing Univ, Dept Polymer Sci & Engn, State Key Lab Coordinat Chem, Sch Chem & Chem Engn,Nanjing Natl Lab Microstruct, Nanjing 210093, Jiangsu, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 41期

基金：

中国国家自然科学基金;

关键词：

C-H functionalization; indoles; N-N bond cleavage; olefination; ruthenium; RHODIUM(III)-CATALYZED ORTHO-ALKENYLATION; INDOLE SYNTHESIS; ISOQUINOLONE SYNTHESIS; O BOND; ACTIVATION; OLEFINATION; VERSATILE; DERIVATIVES; METHOXYBENZAMIDES; PHENOXYACETAMIDES;

D O I：

10.1002/chem.201602936

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A previously elusive Ru-II-catalyzed N-N bond-based traceless C-H functionalization strategy is reported. An N-amino (i.e., hydrazine) group is used for the directed C-H functionalization with either an alkyne or an alkene, affording an indole derivative or olefination product. The synthesis features a broad substrate scope, superior atom and step economy, as well as mild reaction conditions.

引用

页码：14508 / 14512

页数：5

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