Latest Developments in Metalloenzyme Design and Repurposing

被引：24

作者：

Heinisch, Tillmann ^{[1
]}

Ward, Thomas R. ^{[1
]}

机构：

[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2015年 / 21期

关键词：

Artificial metalloenzymes; Redox chemistry; Photocatalysis; Enzyme models; Protein engineering; BETA-BARREL PROTEIN; ARTIFICIAL METALLOENZYMES; OLEFIN CYCLOPROPANATION; COMBINING BIOCATALYSTS; TRANSFER HYDROGENATION; C(SP(3))-H AMINATION; CARBENE TRANSFER; ACTIVE-SITE; ENZYME; MYOGLOBIN;

D O I：

10.1002/ejic.201500408

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In the past decade, artificial metalloenzymes (AMEs) have emerged as attractive alternatives to more traditional homogeneous catalysts and enzymes. This microreview presents a selection of recent achievements in the design of such hybrid catalysts. These include artificial zinc hydrolases and metath-esases, the heme-protein repurposing for C-H, N-H, and S-H insertion reactions, novel light-driven redox hybrid catalysts, novel scaffold proteins, and metallocofactor anchoring techniques and metalloenzyme models.

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页码：3406 / 3418

页数：13

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