Electrophilic Trifluoromethylation by Copper-Catalyzed Addition of CF3-Transfer Reagents to Alkenes and Alkynes

被引：252

作者：

Janson, Par G. ^{[1
]}

Ghoneim, Ibrahim ^{[1
]}

Ilchenko, Nadia O. ^{[1
]}

Szabo, Kalman J. ^{[1
]}

机构：

[1] Stockholm Univ, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 11期

基金：

瑞典研究理事会;

关键词：

ALPHA-TRIFLUOROMETHYLATION; TERMINAL ALKENES; CHEMISTRY; FLUORINE; POSITION; ETHERS; ARENES;

D O I：

10.1021/ol3011419

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regio- and stereoselective Cu-catalyzed addition of the above hypervalent iodine reagent to alkynes and alkenes was achieved. In the presence of Cul, the reaction is suitable to perform trifluoromethyl-benzoyloxylation and trifluoromethyl-halogenation of alkenes and alkynes. Electron-donating substituents accelerate the process, and alkenes react faster than alkynes emphasizing the electrophilic character of the addition reaction.

引用

页码：2882 / 2885

页数：4

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