Unique profile of antimicrobial peptide expression in polymorphic light eruption lesions compared to healthy skin, atopic dermatitis, and psoriasis

被引：27

作者：

Patra, VijayKumar ^{[1
,2
]}

Mayer, Gerlinde ^{[1
,3
]}

Gruber-Wackernagel, Alexandra ^{[1
,3
]}

Horn, Michael ^{[3
]}

Lembo, Serena ^{[4
]}

Wolf, Peter ^{[1
,3
]}

机构：

[1] Med Univ Graz, Res Unit Photodermatol, Graz, Austria

[2] Med Univ Graz, Med Res Ctr, Graz, Austria

[3] Med Univ Graz, Dept Dermatol, Graz, Austria

[4] Univ Salerno, Scuola Med Salernitana, Dept Med Surg & Dent, Fisciano, Italy

来源：

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE | 2018年 / 34卷 / 02期

基金：

奥地利科学基金会;

关键词：

antimicrobial peptides; innate immunity; photosensitivity; polymorphic light eruption; skin microbiome; PLASMACYTOID DENDRITIC CELLS; REGULATORY T-CELLS; B-EXPOSED SKIN; RNASE; 7; UP-REGULATION; DIFFERENTIAL EXPRESSION; BETA-DEFENSINS; VITAMIN-D; INNATE; PROTEIN;

D O I：

10.1111/phpp.12355

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

BackgroundPolymorphic light eruption (PLE) has been attributed to type IV, most likely delayed-type hypersensitivity response (adaptive immunity) but little is known on innate immunity, especially antimicrobial peptides (AMPs) in the disease. Abnormalities in AMP expression have been linked to pathological skin conditions such as atopic dermatitis (AD) and psoriasis. MethodsAntimicrobial peptide profiling was carried out in PLE skin samples (n,12) compared with that of healthy (n,13), atopic (n,6), and psoriatic skin (n,6). ResultsCompared to healthy skin, we observed increased expression of psoriasin and RNAse7 (both mostly in stratum granulosum of the epidermis), HBD-2 (in the cellular infiltrate of the dermis), and LL37 (mostly in and around blood vessels and glands) in PLE lesional skin, a similar expression profile as present in psoriatic skin and different to that of AD (with little or no expression of psoriasin, RNAse7, HBD-2, and LL37). HBD-3 was downregulated in PLE compared to its high expression in the epidermis and dermis of healthy skin, AD, and psoriasis. ConclusionThe unique profile of differentially expressed AMPs in PLE implies a role in the pathophysiology of the disease, possibly directly or indirectly linked to the microbiome of the skin.

引用

页码：137 / 144

页数：8

共 78 条

[1] Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli [J].