Rosacea Pathogenesis

被引：125

作者：

Ahn, Christine S. ^{[1
]}

Huang, William W. ^{[1
]}

机构：

[1] Wake Forest Sch Med, Dept Dermatol, Med Ctr Blvd, Winston Salem, NC 27157 USA

来源：

DERMATOLOGIC CLINICS | 2018年 / 36卷 / 02期

关键词：

Kallikrein; Cathelicidin; Matrix metalloproteinase; Mast cells; Demodex; HUMAN DERMAL FIBROBLASTS; HELICOBACTER-PYLORI; PAPULOPUSTULAR ROSACEA; SKIN INFLAMMATION; EXPRESSION; DEMODEX; ULTRAVIOLET; PROTEINS; CELLS;

D O I：

10.1016/j.det.2017.11.001

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Rosacea is a chronic inflammatory skin disorder that is not fully understood but involves the complex interplay of genetic factors, immune dysregulation, neurovascular dysregulation, presence of microorganisms, and environmental factors. Increased activation of the immune system occurs through multiple stimuli, including increased levels of cathelicidin and kallikrein 5, Toll-like receptor 2, matrix metalloproteinases, and mast cells within the skin. Their effects are enhanced by the presence of microorganisms and external triggers, such as UV radiation.

引用

页码：81 / +

页数：7

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