Complex Virome in a Mesenteric Lymph Node from a Californian Sea Lion (Zalophus californianus)with Polyserositis and Steatitis

被引：15

作者：

Altan, Eda ^{[1
,2
]}

Delaney, Martha A. ^{[3
]}

Colegrove, Kathleen M. ^{[3
]}

Spraker, Terry R. ^{[4
]}

Wheeler, Elizabeth A. ^{[5
]}

Deng, Xutao ^{[1
,2
]}

Li, Yanpeng ^{[1
,2
]}

Gulland, Frances M. D. ^{[6
]}

Delwart, Eric ^{[1
,2
]}

机构：

[1] Vitalant Res Inst, 270 Masonic Ave, San Francisco, CA 94118 USA

[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94118 USA

[3] Univ Illinois, Coll Vet Med, Zool Pathol Program, 3300 Golf Rd, Brookfield, IL 60513 USA

[4] Colorado State Univ, Coll Vet Med & Biomed Sci, Vet Diagnost Lab, 300 West Drake Rd, Ft Collins, CO 80526 USA

[5] Washington State Univ, Coll Vet Med, Dept Vet Microbiol & Pathol, Bustad 471, Pullman, WA 99164 USA

[6] Univ Calif Davis, Karen C Drayer Wildlife Heath Ctr, Sch Vet Med, One Shields Ave, Davis, CA 95616 USA

来源：

VIRUSES-BASEL | 2020年 / 12卷 / 08期

关键词：

California sea lion; protoparvovirus; polyomavirus; virome; next-generation sequencing; granulomatous; perivascular; polyserositis; steatitis; Zalophus californianus; vasculitis; FELINE INFECTIOUS PERITONITIS; MINUTE VIRUS; PARVOVIRUS; ADENOVIRUS; DISEASE; CANINES;

D O I：

10.3390/v12080793

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An emaciated subadult free-ranging California sea lion (Csl orZalophus californianus)died following stranding with lesions similar to 11 other stranded animals characterized by chronic disseminated granulomatous inflammation with necrotizing steatitis and vasculitis, involving visceral adipose tissues in the thoracic and peritoneal cavities. Histologically, affected tissues had extensive accumulations of macrophages with perivascular lymphocytes, plasma cells, and fewer neutrophils. Using viral metagenomics on a mesenteric lymph node six mammalian viruses were identified consisting of novel parvovirus, polyomavirus, rotavirus, anellovirus, and previously described Csl adenovirus 1 and Csl bocavirus 4. The causal or contributory role of these viruses to the gross and histologic lesions of this sea lion remains to be determined.

引用

页数：13