Vitamin C: Antioxidant or pro-oxidant in vivo?

被引：409
作者：
Halliwell, B
机构：
[1] Neurodegenerative Disease Res Centre, Pharmacology Group, King's College, University of London, London SW3 6LX, Manresa Road
来源：
FREE RADICAL RESEARCH | 1996年 / 25卷 / 05期
关键词：
ascorbate; iron; copper; antioxidant; haemochromatosis;
D O I：
10.3109/10715769609149066
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ascorbic acid has a multiplicity of antioxidant properties, but it can exert pro-oxidant effects in vitro, usually by interaction with transition metal ions. It is as yet uncertain that these pro-oxidant effects have any biological relevance: some of the available data are summarized.
引用
收藏
页码：439 / 454
页数：16
相关论文
共 181 条
[1]   MUTAGENICITY OF ASCORBIC-ACID FOR THE PLANT ARABIDOPSIS [J].
ACEDO, GN ;
REDEI, GP ;
SANDHU, SS .
MUTATION RESEARCH, 1984, 129 (01) :57-62
[2]   FREE RADICAL-INDUCED FRAGMENTATION OF PROTEINS BY QUERCETIN [J].
AHMED, MS ;
AINLEY, K ;
PARISH, JH ;
HADI, SM .
CARCINOGENESIS, 1994, 15 (08) :1627-1630
[3]   SERUM NON-TRANSFERRIN-BOUND IRON IN BETA-THALASSEMIA MAJOR PATIENTS TREATED WITH DESFERRIOXAMINE AND L1 [J].
ALREFAIE, FN ;
WICKENS, DG ;
WONKE, B ;
KONTOGHIORGHES, GJ ;
HOFFBRAND, AV .
BRITISH JOURNAL OF HAEMATOLOGY, 1992, 82 (02) :431-436
[4]   OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].
AMES, BN ;
SHIGENAGA, MK ;
HAGEN, TM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922
[5]   A COMPILATION OF SPECIFIC BIMOLECULAR RATE CONSTANTS FOR REACTIONS OF HYDRATED ELECTRONS HYDROGEN ATOMS AND HYDROXYL RADICALS WITH INORGANIC AND ORGANIC COMPOUNDS IN AQUEOUS SOLUTION [J].
ANBAR, M ;
NETA, P .
INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1967, 18 (07) :493-&
[6]   ASCORBATE-INDUCED FREE-RADICAL TOXICITY TO ISOLATED ISLET CELLS [J].
ANDERSSON, M ;
GRANKVIST, K .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1995, 27 (05) :493-498
[7]   IRON OVERLOAD AUGMENTS THE DEVELOPMENT OF ATHEROSCLEROTIC LESIONS IN RABBITS [J].
ARAUJO, JA ;
ROMANO, EL ;
BRITO, BE ;
PARTHE, V ;
ROMANO, M ;
BRACHO, M ;
MONTANO, RF ;
CARDIER, J .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1995, 15 (08) :1172-1180
[8]   INACTIVATION OF ALPHA-ANTIPROTEINASE BY HYDROXYL RADICALS - THE EFFECT OF URIC-ACID [J].
ARUOMA, OI ;
HALLIWELL, B .
FEBS LETTERS, 1989, 244 (01) :76-80
[9]   COPPER-ION-DEPENDENT DAMAGE TO THE BASES IN DNA IN THE PRESENCE OF HYDROGEN-PEROXIDE [J].
ARUOMA, OI ;
HALLIWELL, B ;
GAJEWSKI, E ;
DIZDAROGLU, M .
BIOCHEMICAL JOURNAL, 1991, 273 :601-604
[10]  
ASMUS KD, 1987, RADIOPROTECTORS ANTI, P23
12345678910