A critical review of lipid-based nanoparticles for taxane delivery

被引：158
作者：
Feng, Lan [1 ]
Mumper, Russell J. [1 ,2 ]
机构：
[1] Univ N Carolina, UNC Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
来源：
CANCER LETTERS | 2013年 / 334卷 / 02期
关键词：
Taxane; Lipid-based; Nanoparticles; LOW-DENSITY-LIPOPROTEIN; INTESTINAL-PEPTIDE RECEPTORS; MICROTUBULE ASSEMBLY INVITRO; CONTROLLED DRUG-DELIVERY; RENAL-CELL-CARCINOMA; IN-VITRO; MIXED MICELLES; MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; CREMOPHOR EL;
D O I：
10.1016/j.canlet.2012.07.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Nano-based delivery systems have attracted a great deal of attention in the past two decades as a strategy to overcome the low therapeutic index of conventional anticancer drugs and delivery barriers in solid tumors. Myriads of preclinical studies have been focused on developing nano-based formulations to effectively deliver taxanes, one of the most important and most prescribed anticancer drug types in the clinic. Given the hydrophobic property of taxanes, lipid-based NPs, serve as a viable alternative delivery system. This critical review will provide an overview and perspective of the advancement of lipid-based nanoparticles for taxane delivery. Currently available formulations of taxanes and their drawbacks as well as criteria for idea taxane delivery system will be discussed. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：157 / 175
页数：19
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