Electroconductive materials as biomimetic platforms for tissue regeneration

被引:40
作者
Hosoyama, Katsuhiro [1 ]
Ahumada, Manuel [3 ,4 ]
Goel, Keshav [1 ]
Ruel, Marc [1 ]
Suuronen, Erik J. [1 ]
Alarcon, Emilio I. [1 ,2 ]
机构
[1] Univ Ottawa Heart Inst, Div Cardiac Surg, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada
[2] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada
[3] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[4] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA
基金
加拿大自然科学与工程研究理事会;
关键词
Electroconductive material; Biomimetic templates; Tissue engineering; Nanomaterials; Stem cell; MESENCHYMAL STEM-CELLS; CONDUCTIVE INJECTABLE HYDROGELS; MULTIWALLED CARBON NANOTUBES; DOUBLE-NETWORK HYDROGELS; ELECTRICAL-STIMULATION; CARDIAC DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; ENHANCED DIFFERENTIATION; CARDIOMYOCYTE DIFFERENTIATION; MECHANICAL-PROPERTIES;
D O I
10.1016/j.biotechadv.2019.02.011
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In many diseases, tissue regeneration is compromised and/or insufficient to restore tissue/organ function. Therefore, novel regenerative therapies are being developed to enhance resident and transplanted cell proliferation and functional differentiation. Numerous biomaterials engineered to include nanocomponents have emerged as promising candidates to fulfil the need of mimicking the properties of the healthy extracellular matrix. This is particularly important for tissues that require electroconductive support to achieve optimal cellular function, such as muscles and neurons. In this review, we summarize and discuss the current state-of-theart for electroconductive materials in tissue regeneration, with particular emphasis on materials containing nanocomponents.
引用
收藏
页码:444 / 458
页数:15
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