Automatic regulatory control in type 1 diabetes without carbohydrate counting

被引：51

作者：

Colmegna, Patricio ^{[1
,4
]}

Garelli, Fabricio ^{[2
,4
]}

De Battista, Herman ^{[2
,4
]}

Sanchez-Pena, Ricardo ^{[3
,4
]}

机构：

[1] Univ Nacl Quilmes, Roque Saenz Pena 352, RA-1876 Buenos Aires, DF, Argentina

[2] Univ Nacl La Plata, Calle 48 & 116,CC 91, RA-1900 Buenos Aires, DF, Argentina

[3] Inst Tecnol Buenos Aires, Ave Eduardo Madero 399, RA-1106 Buenos Aires, DF, Argentina

[4] Consejo Nacl Invest Cient & Tecn, Godoy Cruz 2290, RA-1425 Buenos Aires, DF, Argentina

来源：

CONTROL ENGINEERING PRACTICE | 2018年 / 74卷

关键词：

Artificial pancreas; Glucose control; Switched LQG control; Sliding mode control; Insulin on board; LOOP INSULIN DELIVERY; HORMONE ARTIFICIAL PANCREAS; GLUCOSE CONTROL; BLOOD-GLUCOSE; CLINICAL-TRIAL; MEAL DETECTION; MODEL; SYSTEM; SAFETY; FEASIBILITY;

D O I：

10.1016/j.conengprac.2018.02.003

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

A new approach to automatically regulate the glucose level in type 1 diabetes is presented in this work. This is the so-called Automatic Regulation of Glucose (ARG) algorithm, which is based on a switched Linear Quadratic Gaussian (LQG) inner controller, combined with an outer sliding mode safety loop with Insulin on Board (IOB) constraints. In silico and in vivo results without feedforward insulin boluses delivered at meal times indicate that safe blood glucose control can be achieved by the proposed controller. This controller is simple to migrate to well-known hardware platforms, and intuitive to tune using a priori clinical information.

引用

页码：22 / 32

页数：11

共 64 条

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