Recent Advances in Catalytic Sequential Reactions Involving Hydroelement Addition to Carbon-Carbon Multiple Bonds

The article focuses on the recent advances in catalytic sequential reactions involving hydroelement addition to carbon-carbon multiple bonds. Sequential reactions, through the incorporation of several distinct transformations into one single sequence, are one of the most powerful synthetic tools in modern organic chemistry. In general, inexpensive, relatively simple and readily available starting materials can be employed to construct more sophisticated targeted molecules. Meanwhile, combining several distinct transformations into one single sequence greatly increases the complexity of the resulting compounds. Most important of all, such a practically useful 'one-pot' operation simplifies purification of the products, as well as decreasing the cost and effort of synthesis. Sonogashira cross-coupling reactions are important and ubiquitous synthetic tools in the construction of functionalized internal alkynes.