Albusnodin: an acetylated lasso peptide from Streptomyces albus

被引：45

作者：

Zong, Chuhan ^{[1
]}

Cheung-Lee, Wai Ling ^{[2
]}

Elashal, Hader E. ^{[3
]}

Raj, Monika ^{[3
,5
]}

Link, A. James ^{[2
,4
]}

机构：

[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

[2] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA

[3] Seton Hall Univ, Dept Chem, 400 South Orange Ave, S Orange, NJ 07079 USA

[4] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[5] Auburn Univ, Dept Chem & Biochem, Auburn, AL 36849 USA

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 11期

关键词：

GENOME-MINING APPROACH; MICROCIN J25; HETEROLOGOUS EXPRESSION; BIOLOGICAL-PROPERTIES; SECONDARY METABOLITE; MASS-SPECTROMETRY; SEQUENCE-ANALYSIS; NATURAL-PRODUCTS; I-III; ANTAGONIST;

D O I：

10.1039/c7cc08620b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.

引用

收藏

页码：1339 / 1342

页数：4

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