Direct Synthesis of Mono-α-arylated Ketones from Alcohols and Olefins via Ni-Catalyzed Oxidative Cross-Coupling

被引：10
作者：
Yang, Peng-Fei [1 ,2 ]
Shu, Wei [1 ,2 ,3 ]
机构：
[1] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Guangdong, Peoples R China
[2] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China
[3] Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 15期
关键词：
DIRECT INTERMOLECULAR HYDROACYLATION; INTRAMOLECULAR HYDROACYLATION; RHODIUM CATALYSTS; ALDEHYDES; 4-PENTENALS; ACTIVATION; ALKENES; AMIDES; SCOPE;
D O I：
10.1021/acs.orglett.0c02340
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Controlled synthesis of alpha-monoarylated ketones is significant yet challenging due to the site-selectivity issues and nonproductive overarylation reactions. Herein, we reported the direct synthesis of alpha-arylated ketones enabled by Ni-catalyzed dehydrogenative cross-coupling reaction cascade between alcohols and olefins. The use of readily available and cost-effective alcohols and olefins provides a straightforward access to monoarylated ketones in good yields with exclusive selectivity without using any advanced synthetic intermediates.
引用
收藏
页码：6203 / 6208
页数：6
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