Effects of SM-20550, a new Na+/H+ exchange inhibitor, on survival and infarct size in rat myocardial infarction

被引：2

作者：

Yamada, K ^{[1
]}

Sasabe, M ^{[1
]}

Matsui, K ^{[1
]}

Yamamoto, S ^{[1
]}

Ohashi, N ^{[1
]}

机构：

[1] Sumitomo Pharmaceut Co Ltd, Res Ctr, Konohana Ku, Osaka 5540022, Japan

来源：

PHARMACOLOGY | 2002年 / 64卷 / 04期

关键词：

myocardial infarction; myocardial ischemia and reperfusion; Na+/H+ exchanger;

D O I：

10.1159/000056168

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of a novel potent Na+/H+ exchange inhibitor, SM-20550 [N-(aminoiminomethyl)-1,4-dimethyi-1H-indole-2-carboxamide methanesulfonic acid], on survival after myocardial infarction was studied. Anesthetized rats underwent occlusion of the coronary artery (30 min) followed by reperfusion (14 days). SM-20550 was administered intravenously before ischemia (1-day treatment group) or before ischemia and on the 2 days following (3-day treatment group). The infarct size was significantly reduced on the 14th day after surgery by approximately 17 and 20% in 1- and 3-day treatment groups, respectively. The survival rate on day 14 was significantly enhanced in both treatment groups (96%) compared with the vehicle-treated control group (70%). These results suggest that SM-20550 improved survival after myocardial infarction, at least due to its antinecrotic effect. Copyright (C) 2002 S, Karger AG, Basel.

引用

页码：176 / 181

页数：6

共 22 条

[1]

AVKIRAN M, 1996, MYOCARDIAL ISCHEMIA, P299

[2] Antiarrhythmic effects of cariporide, a novel Na+-H+ exchange inhibitor, on reperfusion ventricular arrhythmias in rat hearts [J].

Aye, NN ;

Xue, YX ;

Hashimoto, K .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 339 (2-3) :121-127

[3] LIMITATION OF INFARCT EXPANSION AND VENTRICULAR REMODELING BY LATE REPERFUSION - STUDY OF TIME-COURSE AND MECHANISM IN A RAT MODEL [J].

BOYLE, MP ;

WEISMAN, HF .

CIRCULATION, 1993, 88 (06) :2872-2883

[4] Reduced infarct size in the rabbit heart in vivo by ethylisopropyl-amiloride. A role for Na+/H+ exchange [J].

Bugge, E ;

MunchEllingsen, J ;

Ytrehus, K .

BASIC RESEARCH IN CARDIOLOGY, 1996, 91 (03) :203-209

[5] INDUCTION OF EXPRESSION OF THE SODIUM-HYDROGEN EXCHANGER IN RAT MYOCARDIUM [J].

DYCK, JRB ;

MADDAFORD, TG ;

PIERCE, GN ;

FLIEGEL, L .

CARDIOVASCULAR RESEARCH, 1995, 29 (02) :203-208

[6]

Gumina RJ, 1998, J PHARMACOL EXP THER, V286, P175

[7] Effects of Na+-H+ exchange blocker amiloride on left ventricular remodeling after anterior myocardial infarction in rats [J].

Hasegawa, S ;

Nakano, M ;

Taniguchi, Y ;

Imai, S ;

Murata, K ;

Suzuki, T .

CARDIOVASCULAR DRUGS AND THERAPY, 1995, 9 (06) :823-826

[8] Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion [J].

Humphreys, RA ;

Haist, JV ;

Chakrabarti, S ;

Feng, QP ;

Malcolm, J ;

Arnold, O ;

Karmazyn, M .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 276 (02) :H749-H757

[9] Alteration of intracellular Na+ during ischemia in diabetic rat hearts:: The role of reduced activity in Na+/H+ exchange against stunning [J].

Imahashi, K ;

Hashimoto, K ;

Yamaguchi, H ;

Nishimura, T ;

Kusuoka, H .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1998, 30 (03) :509-517

[10] A Na+-H+ exchange inhibitor (SM-20550) protects from microvascular deterioration and myocardial injury after reperfusion [J].

Ito, Y ;

Imai, S ;

Ui, G ;

Nakano, M ;

Imai, K ;

Kamiyama, H ;

Naganuma, F ;

Matsui, K ;

Ohashi, N ;

Nagai, R .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 374 (03) :355-366

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