Super-paramagnetic responsive silk fibroin/chitosan/magnetite scaffolds with tunable pore structures for bone tissue engineering applications

被引:94
作者
Aliramaji, Shamsa [1 ]
Zamanian, Ali [1 ]
Mozafari, Masoud [1 ]
机构
[1] Mat & Energy Res Ctr, Biomat Res Grp, Nanotechnol & Adv Mat Dept, Tehran, Iran
来源
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 70卷
关键词
Silk fibroin; Chitosan; Responsive scaffolds; Magnetite nanopartides; Bone tissue engineering; Freeze-casting; MAGNETITE NANOPARTICLES; POROUS CERAMICS; CHITOSAN; COMPOSITE; BIOMATERIALS; PROMOTION; PARTICLE; CELLS;
D O I
10.1016/j.msec.2016.09.039
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Tissue engineering is a promising approach in repairing damaged tissues. During the last few years, magnetic nanoparticles have been of great interest in this field of study due to their controlled responsive characteristics in specific external magnetic fields. In this study, after synthesizing iron oxide (magnetite) nanoparticles through a reverse coprecipitation method, silk fibroin/chitosan-based magnetic scaffolds were prepared using different amounts of magnetite nanoparticles (0, 0.5,1 and 2%) by freeze-casting method. The physicochemical activity of the scaffolds was monitored in phosphate-buffered saline (PBS) solution to determine the biodegradation and swelling behaviors. The stability of the magnetite nanoparticles in the fabricated scaffolds was determined by atomic absorption spectroscopy (AAS). Moreover, the cellular activity of the magnetic scaffolds was examined under a static magnetic field. The results showed that the lamellar structured scaffolds having MNPs in the walls could not affect the final structure and deteriorate thebiological characteristics of the scaffolds, while the ability of magnetic responsivity was added to the scaffolds. This study warrants further pre-clinical and clinical evaluations. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:736 / 744
页数:9
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