Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

被引:663
作者
Nishiyama, Akiko [1 ,2 ]
Komitova, Mila [1 ]
Suzuki, Ryusuke [1 ]
Zhu, Xiaoqin [1 ]
机构
[1] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA
[2] Univ Connecticut, Stem Cell Inst, Storrs, CT 06269 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
OLIGODENDROCYTE PRECURSOR CELLS; CENTRAL-NERVOUS-SYSTEM; CHONDROITIN SULFATE PROTEOGLYCAN; NEURAL STEM-CELLS; PDGF ALPHA-RECEPTOR; MULTIPLE-SCLEROSIS LESIONS; SUBCORTICAL WHITE-MATTER; GLIAL PROGENITOR CELLS; RAT CEREBRAL-CORTEX; ADULT SPINAL-CORD;
D O I
10.1038/nrn2495
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
NG2 cells (also known as polydendrocytes) are a population of CNS cells that are distinct from neurons, mature oligodendrocytes, astrocytes and microglia. They can be identified by the expression of the proteoglycan NG2, have a highly branched morphology and are distributed throughout the grey and white matter. They differentiate into oligodendrocytes in vitro and have often been equated with oligodendrocyte precursor cells. However, whether polydendrocytes are multipotential cells that can give rise to neurons and astrocytes as well as oligodendrocytes is now highly debated. Furthermore, electrophysiological studies indicate that polydendrocytes receive synaptic input from neurons, suggesting that they are integrated in the neural network. This Review highlights recent findings and unresolved questions related to the lineage and function of polydendrocytes in the CNS.
引用
收藏
页码:9 / 22
页数:14
相关论文
共 193 条
[31]   Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells [J].
Chatterjee, Nivedita ;
Stegmueller, Judith ;
Schaetzle, Philipp ;
Karram, Khalad ;
Koroll, Michael ;
Werner, Hauke B. ;
Nave, Klaus-Armin ;
Trotter, Jacqueline .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (13) :8310-8317
[32]   Inhibition of axon growth by oligodendrocyte precursor cells [J].
Chen, ZJ ;
Ughrin, Y ;
Levine, JM .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2002, 20 (01) :125-139
[33]   Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells [J].
Cheng, Xiaoxin ;
Wang, Yaping ;
He, Qian ;
Qiu, Mengsheng ;
Whittemore, Scott R. ;
Cao, Qilin .
STEM CELLS, 2007, 25 (12) :3204-3214
[34]   NG2-positive cells in the mouse white and grey matter display distinct physiological properties [J].
Chittajallu, R ;
Aguirre, A ;
Gallo, V .
JOURNAL OF PHYSIOLOGY-LONDON, 2004, 561 (01) :109-122
[35]   NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS [J].
Dawson, MRL ;
Polito, A ;
Levine, JM ;
Reynolds, R .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 24 (02) :476-488
[36]  
Dawson MRL, 2000, J NEUROSCI RES, V61, P471, DOI 10.1002/1097-4547(20000901)61:5<471::AID-JNR1>3.3.CO
[37]  
2-E
[38]   New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors [J].
Dayer, AG ;
Cleaver, KM ;
Abouantoun, T ;
Cameron, HA .
JOURNAL OF CELL BIOLOGY, 2005, 168 (03) :415-427
[39]   Differential responses of spinal axons to transection: influence of the NG2 proteoglycan [J].
de Castro, R ;
Tajrishi, R ;
Claros, J ;
Stallcup, WB .
EXPERIMENTAL NEUROLOGY, 2005, 192 (02) :299-309
[40]   O2A PROGENITOR CELLS TRANSPLANTED INTO THE NEONATAL RAT-BRAIN DEVELOP INTO OLIGODENDROCYTES BUT NOT ASTROCYTES [J].
DELOSMONTEROS, AE ;
ZHANG, MS ;
DEVELLIS, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :50-54