Role of Lipid Rafts/Caveolae in the Anticancer Effect of Endocannabinoids

被引：7
|
作者：
Grimaldi, Claudia [1 ]
Capasso, Anna [1 ]
机构：
[1] Univ Salerno, Dept Pharmaceut & Biomed Sci, I-84084 Fisciano, Salerno, Italy
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2012年 / 12卷 / 11期
关键词：
Endocannabinoids; cancer; lipid rafts; TYPE-1 CANNABINOID RECEPTORS; MEMBRANE DOMAINS; MOLECULAR CHARACTERIZATION; ENDOGENOUS CANNABINOIDS; POSSIBLE INVOLVEMENT; RAFT MICRODOMAINS; PROSTATE-CANCER; PLASMA-MEMBRANE; SYSTEM; ANANDAMIDE;
D O I：
10.2174/138955712802762158
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The endocannabinoid system comprises the cannabinoid receptors type 1 (CB1) and type 2 (CB2), their endogenous ligands (endocannabinoids) and the whole apparatus appointed of their synthesis and degradation. Recent studies investigated the possibility that drugs targeting the endocannabinoid system might be used to retard or block cancer growth. CB1, CB2 and metabolic enzymes of endocannabinoids, function in the context of lipid rafts, specialized membrane microdomains enriched in cholesterol, sphingolipids and glycosphingolipids which may be important in modulating signal transduction. Here, we analysed the role of lipid rafts/caveolae in the intracellular signaling and trafficking of cannabinoid receptor agonist in cancer cells. Perturbation of lipid rafts/caveolae may in fact represent a useful tool for the development of a novel therapy for endocannabinoids-related diseases, such as cancer. Also, we report the more recent developments of endocannabinoids in cancer drug discovery.
引用
收藏
页码：1119 / 1126
页数：8
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