Impacts of Nanoparticles on Cardiovascular Diseases: Modulating Metabolism and Function of Endothelial Cells

被引：13

作者：

Meng, Jie ^{[1
]}

Yang, Xian-da ^{[1
,2
,3
]}

Jia, Lee ^{[4
]}

Liang, Xing-Jie ^{[1
]}

Wang, Chen ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol China, Div Nanomed & Nanobiol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Inst Basic Med Sci, Beijing 100864, Peoples R China

[3] Peking Union Coll, Beijing, Peoples R China

[4] Fuzhou Univ, Coll Chem & Chem Engn, Inst Funct Mat, Fuzhou 350002, Peoples R China

来源：

CURRENT DRUG METABOLISM | 2012年 / 13卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Endothelial cells; nanoparticles; cardiovascular diseases; IRON-OXIDE NANOPARTICLES; ACTIVATED VASCULAR ENDOTHELIUM; WALL CARBON NANOTUBES; SILICA NANOPARTICLES; IN-VITRO; ADHESION MOLECULE; OXIDATIVE STRESS; TISSUE FACTOR; P-SELECTIN; ATHEROSCLEROSIS;

D O I：

10.2174/138920012802850056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial cells have very important functions, one of which is their contribution to regulating molecule and nutrient exchanges between the blood and peripheral tissues. Dysfunction of endothelial cells plays an essential role in the progression of cardiovascular diseases (CVD) such as atherosclerosis and coronary heart disease. With the recent progress of nanotechnology, increasing numbers of studies have focused on the effects of nanoparticles on CVD. In this article, we review the biological characters of endothelial cells, evaluate the impacts of nanoparticles on the behavior and functions of endothelial cells, analyze advantages and disadvantages of various nanoparticles, and discuss potential applications of nanoparticles to CVD treatment.

引用

页码：1123 / 1129

页数：7

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