Effects of Cilnidipine on Serum Uric Acid Level and Urinary Nitrogen Monoxide Excretion in Patients with Hypertension

被引：5
作者：
Hamada, Toshihiro [1 ]
Yamada, Kensaku [2 ]
Mizuta, Einosuke [3 ]
Watanabe, Arisa [1 ]
Osaki, Tomohiro [1 ]
Ishida, Katsunori [1 ]
Hasegawa, Akira [4 ]
Sakata, Shinji [4 ]
Mishima, Mutsuo [4 ]
Ogino, Kazuhide [5 ]
Nosaka, Yoshihito [6 ]
Miyazaki, Satoshi [7 ]
Ohtahara, Akira [3 ]
Ninomiya, Haruaki [8 ]
Kato, Masahiko [2 ]
Yoshida, Akio [4 ]
Taniguchi, Shin-ichi [1 ]
Yamamoto, Kazuhiro [2 ]
Hisatome, Ichiro [4 ]
机构：
[1] Tottori Univ, Fac Med, Dept Reg Med, Yonago, Tottori 6838503, Japan
[2] Tottori Univ, Fac Med, Div Mol Med & Therapeut, Yonago, Tottori 6838503, Japan
[3] Sanin Rosai Hosp, Dept Cardiovasc Med, Yonago, Tottori, Japan
[4] Tottori Univ, Inst Regenerat Med & Biofunct, Grad Sch Med Sci, Yonago, Tottori 6838503, Japan
[5] Tottori Univ Hosp, Ctr Clin Residency Program, Yonago, Tottori 6838503, Japan
[6] Nosaka Med Clin, Yonago, Tottori, Japan
[7] Nojima Hosp, Dept Cardiovasc Med, Kurayoshi, Japan
[8] Tottori Univ, Fac Med, Dept Biol Regulat, Yonago, Tottori 6838503, Japan
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2012年 / 34卷 / 07期
关键词：
cilnidipine; Ca2+ channel blockers; uric acid; nitrogen monoxide; hypertension; SYSTOLIC HYPERTENSION; RENAL-DISEASE; RISK; ALLOPURINOL; PROGRESSION;
D O I：
10.3109/10641963.2012.666600
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of cilnidipine on the serum uric acid level and urinary NO excretion in hypertensive patients were investigated. Blood and urine samples of 16 hypertensive outpatients were collected before and 2 months after cilnidipine therapy (10 mg). The serum uric acid level decreased significantly after cilnidipine treatment, while the uric acid-creatinine clearance ratio was unaffected. The cilnidipine medication produced a significant increase in urinary NO excretion, although amlodipine did not change it significantly. Therefore, cilnidipine has a profound antihypertensive effect and may reduce the serum uric acid level and increase NO production in the kidney.
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收藏
页码：470 / 473
页数：4
相关论文
共 13 条
  • [1] Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP)
    Franse, LV
    Pahor, M
    Di Bari, M
    Shorr, RI
    Wan, JY
    Somes, GW
    Applegate, WB
    [J]. JOURNAL OF HYPERTENSION, 2000, 18 (08) : 1149 - 1154
  • [2] Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk
    Goicoechea, Marian
    Garcia de Vinuesa, Soledad
    Verdalles, Ursula
    Ruiz-Caro, Caridad
    Ampuero, Jara
    Rincon, Abraham
    Arroyo, David
    Luno, Jose
    [J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 5 (08): : 1388 - 1393
  • [3] Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Johnson, RJ
    Kang, DH
    Feig, D
    Kivlighn, S
    Kanellis, J
    Watanabe, S
    Tuttle, KR
    Rodriguez-Iturbe, B
    Herrera-Acosta, J
    Mazzali, M
    [J]. HYPERTENSION, 2003, 41 (06) : 1183 - 1190
  • [4] A new-generation N/L-type calcium channel blocker leads to less activation of the renin-angiotensin system compared with conventional L type calcium channel blocker
    Konoshita, Tadashi
    Makino, Yasukazu
    Kimura, Tomoko
    Fujii, Miki
    Wakahara, Shigeyuki
    Arakawa, Kenichiro
    Inoki, Isao
    Nakamura, Hiroyuki
    Miyamori, Isamu
    [J]. JOURNAL OF HYPERTENSION, 2010, 28 (10) : 2156 - 2160
  • [5] Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism
    Mazzali, M
    Hughes, J
    Kim, YG
    Jefferson, JA
    Kang, DH
    Gordon, KL
    Lan, HY
    Kivlighn, S
    Johnson, RJ
    [J]. HYPERTENSION, 2001, 38 (05) : 1101 - 1106
  • [6] Serum uric acid and renal prognosis in patients with IgA nephropathy
    Ohno, I
    Hosoya, T
    Gomi, H
    Ichida, K
    Okabe, H
    Hikita, M
    [J]. NEPHRON, 2001, 87 (04) : 333 - 339
  • [7] The release of the substrate for xanthine oxidase in hypertensive patients was suppressed by angiotensin converting enzyme inhibitors and α1-blockers
    Ohtahara, A
    Hisatome, I
    Yamamoto, Y
    Furuse, M
    Sonoyama, K
    Furuse, Y
    Hamada, T
    Katoh, M
    Watanabe, M
    Kinugawa, T
    Ogino, K
    Igawa, O
    Shimomura, T
    Murakami, F
    Yamamoto, T
    Shigemasa, C
    [J]. JOURNAL OF HYPERTENSION, 2001, 19 (03) : 575 - 582
  • [8] Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level
    Siu, YP
    Leung, KT
    Tong, MKH
    Kwan, TH
    [J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2006, 47 (01) : 51 - 59
  • [9] EFFECTS OF DILTIAZEM ON PLASMA URIC-ACID LEVEL AND RENAL URIC-ACID EXCRETION IN RATS
    SUGINO, H
    SHIMADA, H
    [J]. JAPANESE JOURNAL OF PHARMACOLOGY, 1989, 50 (02) : 239 - 242
  • [10] Relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men
    Tamba, Sachiko
    Nishizawa, Hitoshi
    Funahashi, Tohru
    Okauchi, Yukiyoshi
    Ogawa, Tomoko
    Noguchi, Midori
    Fujita, Koichi
    Ryo, Miwa
    Kihara, Shinji
    Iwahashi, Hiromi
    Yamagata, Kazuya
    Nakamura, Tadashi
    Shimomura, Iichiro
    Matsuzawa, Yuji
    [J]. INTERNAL MEDICINE, 2008, 47 (13) : 1175 - 1180
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