Anticancer Effects of Huaier are Associated with Down-Regulation of P53

被引：3

作者：

Xu, Xiao ^{[1
]}

Wei, Qiang ^{[1
]}

Wang, Kai ^{[1
]}

Ling, Qi ^{[1
]}

Xie, Haiyang ^{[1
]}

Zhou, Lin ^{[1
]}

Zheng, Shusen ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Zhejiang, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2011年 / 12卷 / 09期

关键词：

Huaier; hepatocellular carcinoma; anticancer effect; animal model; NITROSODIETHYLAMINE INDUCED HEPATOCARCINOGENESIS; HEPATOCELLULAR-CARCINOMA; ALPHA-FETOPROTEIN; GALLIC ACID; RATS; DAMAGE; DNA; DIETHYLNITROSAMINE; RECURRENCE; SILYMARIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study was designed to explore the mechanism of Huaier anticancer effects on experimental hepatocellular cancer (HCC) development. Seventy five rats were divided into 5 groups, administered N-nitrosodiethylamine (groups B, C, D and E) or natural saline (group A). Rats in group C and E were also given Huaier. At the 15 week sacrifice point, the HCC incidence of group C was lower than group correlating with serum AFP. The serum ALT concentration (98.9% greater) and P53 mRNA levels (23.2%) were higher in Group B than group C. Longer term survival rates between group D and E were not significantly different. Huaier can protect liver from chemical injury and furthermore HCC development, possibly with involvement of down-regulation of P53.

引用

页码：2251 / 2254

页数：4

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