Anticancer Effects of Huaier are Associated with Down-Regulation of P53

被引：3
|
作者：
Xu, Xiao [1 ]
Wei, Qiang [1 ]
Wang, Kai [1 ]
Ling, Qi [1 ]
Xie, Haiyang [1 ]
Zhou, Lin [1 ]
Zheng, Shusen [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Zhejiang, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2011年 / 12卷 / 09期
关键词：
Huaier; hepatocellular carcinoma; anticancer effect; animal model; NITROSODIETHYLAMINE INDUCED HEPATOCARCINOGENESIS; HEPATOCELLULAR-CARCINOMA; ALPHA-FETOPROTEIN; GALLIC ACID; RATS; DAMAGE; DNA; DIETHYLNITROSAMINE; RECURRENCE; SILYMARIN;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study was designed to explore the mechanism of Huaier anticancer effects on experimental hepatocellular cancer (HCC) development. Seventy five rats were divided into 5 groups, administered N-nitrosodiethylamine (groups B, C, D and E) or natural saline (group A). Rats in group C and E were also given Huaier. At the 15 week sacrifice point, the HCC incidence of group C was lower than group correlating with serum AFP. The serum ALT concentration (98.9% greater) and P53 mRNA levels (23.2%) were higher in Group B than group C. Longer term survival rates between group D and E were not significantly different. Huaier can protect liver from chemical injury and furthermore HCC development, possibly with involvement of down-regulation of P53.
引用
收藏
页码：2251 / 2254
页数：4
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