A d-f heteronuclear complex for dual-mode phosphorescence and magnetic resonance imaging

被引：44
|
作者：
Yang, Hong [2 ,3 ]
Ding, Liang [2 ,3 ]
An, Lu [2 ,3 ]
Xiang, Zheyuan [2 ,3 ]
Chen, Min [1 ]
Zhou, Jing [1 ]
Li, Fuyou [1 ]
Wu, Dongmei [4 ]
Yang, Shiping [2 ,3 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[2] Shanghai Normal Univ, Dept Chem, Key Lab Resource Chem, Minist Educ, Shanghai 200234, Peoples R China
[3] Shanghai Normal Univ, Dept Chem, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China
[4] E China Normal Univ, Dept Phys, Shanghai Key Lab Magnet Resonance, Shanghai 200062, Peoples R China
来源：
BIOMATERIALS | 2012年 / 33卷 / 33期
基金：
中国国家自然科学基金;
关键词：
d-f heteronuclear complex; Ir-Gd complex; Phosphorescence imaging; Magnetic resonance imaging; UP-CONVERSION LUMINESCENCE; IRIDIUM(III) COMPLEXES; MRI; NANOPHOSPHORS; NANOCRYSTALS; PROBES; AGENTS;
D O I：
10.1016/j.biomaterials.2012.07.067
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A d-f heteronuclear complex (Ir-Gd) by coupling an iridium(III) complex to a macrocycle-based gadolinium complex has been developed as as a dual-mode bioimaging probe for luminescence imaging and magnetic resonance imaging (MRI). The cyclometalated iridium complex showed an intense visible metal-to-ligand charge transfer (MLCT) absorption and strong yellow phosphorescent luminescence. It has specificity of staining in murine mitochondria confirmed by confocal laser scanning microscopy. The macrocycle-based gadolinium complex provides the longitudinal relaxivity of 3.36 mM(-1)s(-1) on a 3 T system, which has been applied to MRI for liver in mice. Furthermore, the biodistribution of Ir-Gd has been investigated using inductively coupled plasma atomic emission spectroscopy (ICP-AES) analyses. Such platform should be extended to further applications in the identification and diagnosis of liver diseases. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8591 / 8599
页数：9
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