Substrate-free and label-free electrocatalysis-assisted biosensor for sensitive detection of microRNA in lung cancer cells

被引：29

作者：

Cui, Lin ^{[1
]}

Wang, Meng ^{[1
]}

Sun, Bing ^{[2
]}

Ai, Shiyun ^{[3
]}

Wang, Shaocong ^{[1
]}

Zhang, Chun-yang ^{[1
]}

机构：

[1] Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Shandong Prov Key Lab Clean Prod Fine Chem, Coll Chem Chem Engn & Mat Sci,Minist Educ,Key Lab, Jinan 250014, Shandong, Peoples R China

[2] China Univ Geosci Beijing, Sch Sci, Beijing 100183, Peoples R China

[3] Shandong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CARBON NANOTUBES; COPPER NANOPARTICLES; GOLD NANOPARTICLES; AMPLIFICATION; PEROXIDASE; NITROGEN; SIGNAL; NANOMATERIALS; CATALYSTS; ENZYME;

D O I：

10.1039/c8cc09688k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We develop a substrate-free and label-free electrocatalysis-assisted biosensor for sensitive detection of microRNA using the iron-embedded nitrogen-rich carbon nanotubes (FeCN) as the catalytic elements. This biosensor exhibits excellent selectivity and high sensitivity with a detection limit of 8.53 x 10(-16) M and a large dynamic range of 6 orders of magnitude. It can be further applied for accurate quantification of microRNA in lung cancer cells.

引用

收藏

页码：1172 / 1175

页数：4

相关论文

共 49 条

[1]

[Anonymous], ENG OPTIM

[2] Fabricating Metal@N-Doped Carbon Catalysts via a Thermal Method [J].

Cao, Yueling ;

Zhao, Bowen ;

Bao, Xiaobing ;

Wang, Yong .

ACS CATALYSIS, 2018, 8 (08) :7077-7085

[3] An electrochemical biosensor based on the enhanced quasi-reversible redox signal of prussian blue generated by self-sacrificial label of iron metal-organic framework [J].

Cui, Lin ;

Hu, Juan ;

Li, Chen-chen ;

Wang, Cheng-ming ;

Zhang, Chun-yang .

BIOSENSORS & BIOELECTRONICS, 2018, 122 :168-174

[4] Mimic Peroxidase- and Bi2S3 Nanorod-Based Photoelectrochemical Biosensor for Signal-On Detection of Polynucleotide Kinase [J].

Cui, Lin ;

Hu, Juan ;

Wang, Meng ;

Diao, Xing-kang ;

Li, Chen-chen ;

Zhang, Chun-yang .

ANALYTICAL CHEMISTRY, 2018, 90 (19) :11478-11485

[5] Isothermal Amplification for MicroRNA Detection: From the Test Tube to the Cell [J].

Deng, Ruijie ;

Zhang, Kaixiang ;

Li, Jinghong .

ACCOUNTS OF CHEMICAL RESEARCH, 2017, 50 (04) :1059-1068

[6] M3C (M: Fe, Co, Ni) Nanocrystals Encased in Graphene Nanoribbons: An Active and Stable Bifunctional Electrocatalyst for Oxygen Reduction and Hydrogen Evolution Reactions [J].

Fan, Xiujun ;

Peng, Zhiwei ;

Ye, Ruquan ;

Zhou, Haiqing ;

Guo, Xia .

ACS NANO, 2015, 9 (07) :7407-7418

[7] A bimetallic nanoparticle/graphene oxide/thionine composite-modified glassy carbon electrode used as a facile ratiometric electrochemical sensor for sensitive uric acid determination [J].

Gao, Xiaohui ;

Gui, Rijun ;

Xu, Kendrick Qizhou ;

Guo, Huijun ;

Jin, Hui ;

Wang, Zonghua .

NEW JOURNAL OF CHEMISTRY, 2018, 42 (18) :14796-14804

[8] Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage [J].

Ge, Cuicui ;

Fang, Ge ;

Shen, Xiaomei ;

Chong, Yu ;

Wamer, Wayne G. ;

Gao, Xingfa ;

Chai, Zhifang ;

Chen, Chunying ;

Yin, Jun-Jie .

ACS NANO, 2016, 10 (11) :10436-10445

[9] HEAT-TREATED POLYACRYLONITRILE-BASED CATALYSTS FOR OXYGEN ELECTROREDUCTION [J].

GUPTA, S ;

TRYK, D ;

BAE, I ;

ALDRED, W ;

YEAGER, E .

JOURNAL OF APPLIED ELECTROCHEMISTRY, 1989, 19 (01) :19-27

[10] Nitrogen-Doped Carbon Nanomaterials as Highly Active and Specific Peroxidase Mimics [J].

Hu, Yihui ;

Gao, Xuejiao J. ;

Zhu, Yunyao ;

Muhammad, Faheem ;

Tan, Shihua ;

Cao, Wen ;

Lin, Shichao ;

Jin, Zhong ;

Gao, Xingfa ;

Wei, Hui .

CHEMISTRY OF MATERIALS, 2018, 30 (18) :6431-6439

← 1 2 3 4 5 →