Bone Morphogenetic Protein in Spine Surgery: Current and Future Uses

被引：86
作者：
Even, Jesse [1 ]
Eskander, Mark [1 ]
Kang, James [1 ]
机构：
[1] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA
来源：
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS | 2012年 / 20卷 / 09期
关键词：
LUMBAR INTERBODY FUSION; EMERGING SAFETY CONCERNS; ANTERIOR; RHBMP-2; ARTHRODESIS; OUTCOMES; TRIALS; GRAFT; AUTOGRAFT; HARVEST;
D O I：
10.5435/JAAOS-20-09-547
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
The clinical use of bone morphogenetic protein (BMP) in spinal fusion surgery has recently become controversial. After its approval, by the US FDA in July 2002, BMP was adopted by many spine surgeons as a replacement for the more traditional iliac crest bone graft to avoid the complications associated with bone graft harvest. However, as broad clinical use escalated, reports increased of potentially serious complications associated with BMP. Controversy continues, particularly regarding the safety of BMP and whether it should routinely replace iliac crest bone graft for spinal fusion surgery.
引用
收藏
页码：547 / 552
页数：6
相关论文
共 38 条
[1]   Comparison of anterior and posterior iliac crest bone grafts in terms of harvest-site morbidity and functional outcomes [J].
Ahlmann, E ;
Patzakis, M ;
Roidis, N ;
Shepherd, L ;
Holtom, P .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2002, 84A (05) :716-720
[2]   A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SR™ allograft ring and the ATLANTIS™ anterior cervical plate [J].
Baskin, DS ;
Ryan, P ;
Sonntag, V ;
Westmark, R ;
Widmayer, MA .
SPINE, 2003, 28 (12) :1219-1224
[3]   Anterior cervical discectomy and fusion involving a polyetheretherketone spacer and bone morphogenetic protein [J].
Boakye, M ;
Mummaneni, PV ;
Garrett, M ;
Rodts, G ;
Haid, R .
JOURNAL OF NEUROSURGERY-SPINE, 2005, 2 (05) :521-525
[4]   Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans - A prospective, randomized clinical pilot trial - 2002 Volvo Award in clinical studies [J].
Boden, SD ;
Kang, J ;
Sandhu, H ;
Heller, JG .
SPINE, 2002, 27 (23) :2662-2673
[5]   Influence of rhBMP-2 on the healing patterns associated with allograft interbody constructs in comparison with autograft [J].
Burkus, JK ;
Sandhu, HS ;
Gornet, MF .
SPINE, 2006, 31 (07) :775-781
[6]   Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages [J].
Burkus, JK ;
Gornet, MF ;
Dickman, CA ;
Zdeblick, TA .
JOURNAL OF SPINAL DISORDERS & TECHNIQUES, 2002, 15 (05) :337-349
[7]   Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2 [J].
Burkus, JK ;
Transfeldt, EE ;
Kitchel, SH ;
Watkins, RG ;
Balderston, RA .
SPINE, 2002, 27 (21) :2396-2408
[8]  
Carragee EJ, 2011, SPINE J, V11, P1082
[9]   Reply to "A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned" response [J].
Carragee, Eugene J. ;
Hurwitz, Eric L. ;
Weiner, Bradley K. .
SPINE JOURNAL, 2011, 11 (11) :1083-1086
[10]   Retrograde ejaculation after anterior lumbar interbody fusion using rhBMP-2: a cohort controlled study [J].
Carragee, Eugene J. ;
Mitsunaga, Kyle A. ;
Hurwitz, Eric L. ;
Scuderi, Gaetano J. .
SPINE JOURNAL, 2011, 11 (06) :511-516
1234