Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts

被引：108
作者：
Yang, Yang [1 ]
Oldenhuis, Nathan J. [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 02期
基金：
美国国家卫生研究院;
关键词：
cross-coupling; heterocycles; homogeneous catalysis; organozinc reagents; palladacycle precatalysts; HIGHLY-ACTIVE CATALYST; ORGANOZINC REAGENTS; BORONIC ACIDS; PALLADIUM; ARYL; HETEROARYL; HALIDES; BULKY; ARYLATION; CHLORIDES;
D O I：
10.1002/anie.201207750
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd0 species. Significantly, a wide range of challenging heterocyclic and polyfluorinated aromatic substrates can be employed to give products in excellent yields. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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页码：615 / 619
页数：5
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