Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness

被引：13

作者：

Streit, Fabian ^{[1
]}

Witt, Stephanie H. ^{[1
,2
]}

Awasthi, Swapnil ^{[3
]}

Foo, Jerome C. ^{[1
]}

Jungkunz, Martin ^{[4
,5
]}

Frank, Josef ^{[1
]}

Colodro-Conde, Lucia ^{[6
,7
,8
]}

Hindley, Guy ^{[9
,10
]}

Smeland, Olav B. ^{[9
,11
]}

Maslahati, Tolou ^{[12
,13
,14
,15
,16
,17
]}

Schwarze, Cornelia E. ^{[18
]}

Dahmen, Norbert ^{[19
]}

Schott, Bjorn H. ^{[3
,20
,21
]}

Kleindienst, Nikolaus ^{[4
]}

Hartmann, Annette ^{[22
]}

Giegling, Ina ^{[23
]}

Zillich, Lea ^{[1
]}

Sirignano, Lea ^{[1
]}

Poisel, Eric ^{[1
]}

Chen, Chi-Hua ^{[24
]}

Noethen, Markus M. ^{[25
]}

Mobascher, Arian ^{[26
]}

Rujescu, Dan ^{[22
]}

Lieb, Klaus ^{[19
]}

Roepke, Stefan ^{[12
,13
,14
,15
,16
,17
]}

Schmahl, Christian ^{[4
]}

Bohus, Martin ^{[4
,27
]}

Ripke, Stephan ^{[3
,28
,29
,30
,31
]}

Rietschel, Marcella ^{[1
]}

Andreassen, Ole A. ^{[32
,33
,34
]}

机构：

[1] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany

[2] Heidelberg Univ, Med Fac Mannheim, Ctr Innovat Psychiat & Psychotherapy, Cent Inst Mental Hlth, Mannheim, Germany

[3] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Mitte, Berlin, Germany

[4] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychosomat Med & Psychotherapy, Mannheim, Germany

[5] German Canc Res Ctr, Natl Ctr Tumor Dis, Sect Translat Med Eth, Heidelberg, Germany

[6] QIMR Berghofer Med Res Inst Brisbane, Brisbane, Qld, Australia

[7] Univ Queensland, Sch Psychol, Brisbane, Qld, Australia

[8] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld, Australia

[9] Oslo Univ Hosp, Ctr Mental Disorders Res, Div Mental Hlth & Addict, NORMENT, Oslo, Norway

[10] Kings Coll London, Inst Psychiat Psychol & Neurosci, Psychosis Studies, 16 De Crespigny Pk, London SE5 8AB, England

[11] Univ Oslo, Inst Clin Med, Oslo, Norway

[12] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

[13] Free Univ Berlin, Berlin, Germany

[14] Humboldt Univ, Berlin, Germany

[15] Berlin Inst Hlth, Berlin, Germany

[16] Campus Benjamin Franklin, Berlin, Germany

[17] Charite Med Fac Berlin, Berlin, Germany

[18] Heidelberg Univ, Dept Dev & Biol Psychol, Heidelberg, Germany

[19] Univ Med Ctr, Dept Psychiat & Psychotherapy, Mainz, Germany

[20] Leibniz Inst Neurobiol, Magdeburg, Germany

[21] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

[22] Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria

[23] Med Univ Vienna, Dept Neurol, Vienna, Austria

[24] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA

[25] Univ Hosp Bonn, Inst Human Genet, Bonn, Germany

[26] St Elisabeth Krankenhaus Lahnstein, Dept Psychiat & Psychotherapy, Lahnstein, Germany

[27] Ruhr Univ Bochum, Dept Clin Psychol & Psychotherapy, Bochum, Germany

[28] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA

[29] Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA 02142 USA

[30] Massachusetts Gen Hosp, Boston, MA 02114 USA

[31] Harvard Med Sch, Analyt & Translat Genet Unit, Boston, MA 02115 USA

[32] Univ Oslo, NORMENT Ctr, Oslo, Norway

[33] Univ Oslo, Inst Clin Med, KG Jebsen Ctr Neurodev Disorders, Oslo, Norway

[34] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway

来源：

TRANSLATIONAL PSYCHIATRY | 2022年 / 12卷 / 01期

关键词：

5-FACTOR MODEL; TRAITS; HALLUCINATIONS; RISK;

D O I：

10.1038/s41398-022-01912-2

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Both environmental (e.g. interpersonal traumatization during childhood and adolescence) and genetic factors may contribute to the development of Borderline Personality Disorder (BPD). Twin studies assessing borderline personality symptoms/features in the general population indicate that genetic factors underlying these symptoms/features are shared in part with the personality traits of the Five Factor Model (FFM) of personality-the "Big Five". In the present study, the genetic overlap of BPD with the Big Five -Openness to Experience, Conscientiousness, Extraversion, Agreeableness, and Neuroticism- was assessed. Linkage disequilibrium score regression was used to calculate genetic correlations between a genome-wide association study (GWAS) in central European populations on BPD (N = 2543) and GWAS on the Big Five (N = 76,551-122,886, Neuroticism N = 390,278). Polygenic scores (PGS) were calculated to test the association of the genetic disposition for the personality traits with BPD case-control status. Significant positive genetic correlations of BPD were found with Neuroticism (rg = 0.34, p = 6.3*10(-5)) and Openness (rg = 0.24, p = 0.036), but not with the other personality traits (all | rg | <0.14, all p > 0.30). A cluster and item-level analysis showed positive genetic correlations of BPD with the Neuroticism clusters "Depressed Affect" and "Worry", and with a broad range of Neuroticism items (N = 348,219-376,352). PGS analyses confirmed the genetic correlations, and found an independent contribution of the personality traits to BPD risk. The observed associations indicate a partially shared genetic background of BPD and the personality traits Neuroticism and Openness. Larger GWAS of BPD and the "Big Five" are needed to further explore the role of personality traits in the etiology of BPD.

引用

页数：8

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