MicroRNA in cancer: New hopes for antineoplastic chemotherapy

被引：38
作者：
Di Leva, Gianpiero [1 ]
Briskin, Daniel [1 ]
Croce, Carlo M. [1 ]
机构：
[1] Ohio State Univ, Dept Mol Virol Immunol & Human Genet, Columbus, OH 43210 USA
来源：
UPSALA JOURNAL OF MEDICAL SCIENCES | 2012年 / 117卷 / 02期
关键词：
Cancer; microRNAs; non-coding RNAs; TUMOR-SUPPRESSOR GENE; CELL-DEATH; 4; PROSTATE-CANCER; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; MIR-200; FAMILY; GASTRIC-CANCER; LUNG-CANCER; IN-VIVO; EXPRESSION;
D O I：
10.3109/03009734.2012.660551
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
MicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs that are evolutionarily conserved and widely distributed among species. Their major function is to negatively regulate mRNA target genes, and miRNA expression has been found to be deregulated in all human cancers, where miRNAs play critical roles in tumorigenesis, functioning either as tumor suppressors or as oncogenes. This review provides a current overview of the connection between miRNAs and cancer by covering the recent advances in miRNA involvement in human cancer including initiation, growth, invasion, and metastasis. We will also highlight the literature where application of miRNAs has created the foundation for the development of potential future miRNA therapy.
引用
收藏
页码：202 / 216
页数：15
相关论文
共 88 条
  • [1] Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells
    Akao, Yukihiro
    Noguchi, Shunsuke
    Iio, Akio
    Kojima, Keitaro
    Takagi, Takeshi
    Naoe, Tomoki
    [J]. CANCER LETTERS, 2011, 300 (02) : 197 - 204
  • [2] Transcriptional Repression of miR-34 Family Contributes to p63-Mediated Cell Cycle Progression in Epidermal Cells
    Antonini, Dario
    Russo, Monia T.
    De Rosa, Laura
    Gorrese, Marisa
    Del Vecchio, Luigi
    Missero, Caterina
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (05) : 1249 - 1257
  • [3] MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    Asangani, I. A.
    Rasheed, S. A. K.
    Nikolova, D. A.
    Leupold, J. H.
    Colburn, N. H.
    Post, S.
    Allgayer, H.
    [J]. ONCOGENE, 2008, 27 (15) : 2128 - 2136
  • [4] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
    Bartel, David P.
    [J]. CELL, 2007, 131 (04) : 11 - 29
  • [5] The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
    Bonci, Desiree
    Coppola, Valeria
    Musumeci, Maria
    Addario, Antonio
    Giuffrida, Raffaella
    Memeo, Lorenzo
    D'Urso, Leonardo
    Pagliuca, Alfredo
    Biffoni, Mauro
    Labbaye, Catherine
    Bartucci, Monica
    Muto, Giovanni
    Peschle, Cesare
    De Maria, Ruggero
    [J]. NATURE MEDICINE, 2008, 14 (11) : 1271 - 1277
  • [6] Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression
    Bueno, Maria J.
    Perez de Castro, Ignacio
    de Cedron, Marta Gomez
    Santos, Javier
    Calin, George A.
    Cigudosa, Juan C.
    Croce, Carlo M.
    Fernandez-Piqueras, Jose
    Malumbres, Marcos
    [J]. CANCER CELL, 2008, 13 (06) : 496 - 506
  • [7] Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    Calin, GA
    Sevignani, C
    Dan Dumitru, C
    Hyslop, T
    Noch, E
    Yendamuri, S
    Shimizu, M
    Rattan, S
    Bullrich, F
    Negrini, M
    Croce, CM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) : 2999 - 3004
  • [8] A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    Calin, GA
    Ferracin, M
    Cimmino, A
    Di Leva, G
    Shimizu, M
    Wojcik, SE
    Iorio, MV
    Visone, R
    Sever, NI
    Fabbri, M
    Iuliano, R
    Palumbo, T
    Pichiorri, F
    Roldo, C
    Garzon, R
    Sevignani, C
    Rassenti, L
    Alder, H
    Volinia, S
    Liu, CG
    Kipps, TJ
    Negrini, M
    Croce, CM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) : 1793 - 1801
  • [9] MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias
    Calin, GA
    Liu, CG
    Sevignani, C
    Ferracin, M
    Felli, N
    Dumitru, CD
    Shimizu, M
    Cimmino, A
    Zupo, S
    Dono, M
    Dell'Aquila, ML
    Alder, H
    Rassenti, L
    Kipps, TJ
    Bullrich, F
    Negrini, M
    Croce, CM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) : 11755 - 11760
  • [10] MicroRNA signatures in human cancers
    Calin, George A.
    Croce, Carlo M.
    [J]. NATURE REVIEWS CANCER, 2006, 6 (11) : 857 - 866
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