Multicomponent eco-friendly synthesis of 3,4-dihydropyrimidine-2-(1H)-ones using an organocatalyst Lactic acid

被引：30
作者：
Suresh [1 ]
Saini, Anil [1 ]
Kumar, Dhruva [1 ]
Sandhu, Jagir S. [1 ]
机构：
[1] Punjabi Univ, Dept Chem, Patiala 147002, Punjab, India
来源：
GREEN CHEMISTRY LETTERS AND REVIEWS | 2009年 / 2卷 / 01期
关键词：
aldehyde; 1,3-dicarbonyl compound; urea; Lactic acid; CALCIUM-CHANNEL BLOCKERS; ONE-POT SYNTHESIS; SOLVENT-FREE CONDITIONS; BIGINELLI REACTION; CONDENSATION REACTION; LITHIUM BROMIDE; CATALYST; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; ESTERS; WATER;
D O I：
10.1080/17518250902973833
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Biginelli compounds 3,4-dihydropyrimidine-2-(1H)-ones are synthesized in high yields via eco-friendly simple reaction procedure using Lactic acid: organocatalyst. The new method reported herein is green and is free of formation of any hazardous by products. The process has significant advantages over other reported methods. [GRAPHICS] .
引用
收藏
页码：29 / 33
页数：5
相关论文
共 43 条
[1]   Why organocatalysis? [J].
Alexakis, Alexandre .
CHIMIA, 2007, 61 (05) :212-212
[2]   DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .3. 3-CARBAMOYL-4-ARYL-1,2,3,4-TETRAHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS ORALLY EFFECTIVE ANTIHYPERTENSIVE AGENTS [J].
ATWAL, KS ;
SWANSON, BN ;
UNGER, SE ;
FLOYD, DM ;
MORELAND, S ;
HEDBERG, A ;
OREILLY, BC .
JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :806-811
[3]   DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS 51 - BICYCLIC DIHYDROPYRIMIDINES AS POTENT MIMICS OF DIHYDROPYRIDINES [J].
ATWAL, KS ;
MORELAND, S .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (06) :291-294
[4]   DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .2. 3-SUBSTITUTED-4-ARYL-1,4-DIHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS POTENT MIMICS OF DIHYDROPYRIDINES [J].
ATWAL, KS ;
ROVNYAK, GC ;
KIMBALL, SD ;
FLOYD, DM ;
MORELAND, S ;
SWANSON, BN ;
GOUGOUTAS, JZ ;
SCHWARTZ, J ;
SMILLIE, KM ;
MALLEY, MF .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (09) :2629-2635
[5]   The Biginelli condensation:: A novel and efficient regioselective synthesis of dihydropyrimidin-2(1H)-ones using lithium bromide [J].
Baruah, PP ;
Gadhwal, S ;
Prajapati, D ;
Sandhu, JS .
CHEMISTRY LETTERS, 2002, (10) :1038-1039
[6]  
Biginelli P, 1891, CHEM BER, V24, P1317
[7]  
Biginelli P., 1891, CHEM BER-RECL, V24, P2962, DOI [DOI 10.1002/CBER.189102402126, 10.1002/cber.189102402126]
[8]  
Biginelli P., 1889, GAZZ CHIM ITAL, V19, P212
[9]  
Biginelli P., 1893, GAZZ CHIM ITAL, V23, P360
[10]   Large scale Biginelli reaction via water-based biphasic media: a green chemistry strategy [J].
Bose, AK ;
Manhas, MS ;
Pednekar, S ;
Ganguly, SN ;
Dang, H ;
He, W ;
Mandadi, A .
TETRAHEDRON LETTERS, 2005, 46 (11) :1901-1903
12345