Vasopressin in Vasodilatory Shock

被引：20

作者：

Ukor, Ida-Fong ^{[1
]}

Walley, Keith R. ^{[1
]}

机构：

[1] Univ British Columbia, Div Crit Care Med, Ctr Heart Lung Innovat, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada

来源：

CRITICAL CARE CLINICS | 2019年 / 35卷 / 02期

基金：

加拿大健康研究院;

关键词：

Vasopressin; Antidiuretic hormone; Vasodilatory shock; Vasoplegia; Sepsis; CENTRAL-NERVOUS-SYSTEM; SENSITIVE K+ CHANNELS; NITRIC-OXIDE SYNTHASE; SEPTIC SHOCK; ARGININE-VASOPRESSIN; HYPERPOLARIZING FACTOR; DOWN-REGULATION; CARDIOVASCULAR-SYSTEM; POTASSIUM CHANNELS; ENDOTHELIAL-CELLS;

D O I：

10.1016/j.ccc.2018.11.004

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Vasodilatory shock is the final common pathway for all forms of severe shock, with sepsis the most common primary etiology and the leading cause of critical illness related mortality. The pathophysiology of this condition remains incompletely elucidated. Deficiency of the neuropeptide hormone vasopressin seems to play a significant role. The physiology of vasopressin and its interaction with the pathophysiology of vasodilatory shock are described in this review. A brief review of the major randomized controlled trials assessing the efficacy and safety of vasopressin and its analogs in this complex patient cohort is also provided.

引用

页码：247 / +

页数：16

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