Mortality and complications after prostate biopsy in the Prostate, Lung, Colorectal and Ovarian Cancer Screening (PLCO) trial

被引：62

作者：

Pinsky, Paul F. ^{[1
]}

Parnes, Howard L. ^{[1
]}

Andriole, Gerald ^{[2
]}

机构：

[1] NCI, Canc Prevent Div, Bethesda, MD 20892 USA

[2] Washington Univ, Sch Med, St Louis, MO USA

来源：

BJU INTERNATIONAL | 2014年 / 113卷 / 02期

关键词：

prostate biopsy; complications; mortality; prostate-specific antigen; PSA;

D O I：

10.1111/bju.12368

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To examine mortality and morbidity after prostate biopsy in the intervention arm of the Prostate, Lung, Colorectal and Ovarian Cancer Screening (PLCO) trial. Subjects and Methods Abstractors from the PLCO trial recorded the types and dates of diagnostic follow-up procedures after positive screens and documented the types and dates of resultant complications. Cancers and deaths among the participants were tracked. The mortality rate in the 120-day period after prostate biopsy was compared with a control rate of deaths in the 120-day period after a negative screen in men without biopsy. Multivariate analysis was performed to control for potential confounders, including age, comorbidities and smoking. Rates of any complication, infectious and non-infectious complications were computed among men with a negative biopsy. Multivariate analysis was used to examine the risk factors for complications. Results Of the 37345 men enrolled in the PLCO trial (intervention arm), 4861 had at least one biopsy after a positive screen and 28661 had a negative screen and no biopsy. The 120-day mortality rate after biopsy was 0.95 (per 1000), compared with the control group rate of 1.8; the multivariate relative risk was 0.49 (95% CI: 0.2-1.1). Among 3706 negative biopsies, the rates (per 1000) of any complication, infectious and non-infections complications were 20.2, 7.8 and 13.0, respectively. A history of prostate enlargement or inflammation was significantly associated with higher rates of both infectious (odds ratio [OR] = 3.7) and non-infectious (OR = 2.2) complications. Black race was associated with a higher infectious complications rate (OR = 7.1) and repeat biopsy was associated with lower rates of non-infectious complications (OR = 0.3). Conclusion Mortality rates were not found to be higher after prostate biopsy in the PLCO trial and complications were relatively infrequent, with several risk factors identified.

引用

页码：254 / 259

页数：6

共 12 条

[1] Prostate Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: Mortality Results after 13 Years of Follow-up [J].

Andriole, Gerald L. ;

Crawford, E. David ;

Grubb, Robert L., III ;

Buys, Saundra S. ;

Chia, David ;

Church, Timothy R. ;

Fouad, Mona N. ;

Isaacs, Claudine ;

Kvale, Paul A. ;

Reding, Douglas J. ;

Weissfeld, Joel L. ;

Yokochi, Lance A. ;

O'Brien, Barbara ;

Ragard, Lawrence R. ;

Clapp, Jonathan D. ;

Rathmell, Joshua M. ;

Riley, Thomas L. ;

Hsing, Ann W. ;

Izmirlian, Grant ;

Pinsky, Paul F. ;

Kramer, Barnett S. ;

Miller, Anthony B. ;

Gohagan, John K. ;

Prorok, Philip C. .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2012, 104 (02) :125-132

[2] Mortality Results from a Randomized Prostate-Cancer Screening Trial [J].

Andriole, Gerald L. ;

Grubb, Robert L., III ;

Buys, Saundra S. ;

Chia, David ;

Church, Timothy R. ;

Fouad, Mona N. ;

Gelmann, Edward P. ;

Kvale, Paul A. ;

Reding, Douglas J. ;

Weissfeld, Joel L. ;

Yokochi, Lance A. ;

Crawford, E. David ;

O'Brien, Barbara ;

Clapp, Jonathan D. ;

Rathmell, Joshua M. ;

Riley, Thomas L. ;

Hayes, Richard B. ;

Kramer, Barnett S. ;

Izmirlian, Grant ;

Miller, Anthony B. ;

Pinsky, Paul F. ;

Prorok, Philip C. ;

Gohagan, John K. ;

Berg, Christine D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (13) :1310-1319

[3] Critical role of prostate biopsy mortality in the number of years of life gained and lost within a prostate cancer screening programme [J].

Boniol, Mathieu ;

Boyle, Peter ;

Autier, Philippe ;

Ruffion, Alain ;

Perrin, Paul .

BJU INTERNATIONAL, 2012, 110 (11) :1648-1652

[4] No excess mortality after prostate biopsy: results from the European Randomized Study of Screening for Prostate Cancer [J].

Carlsson, Sigrid V. ;

Holmberg, Erik ;

Moss, Sue M. ;

Roobol, Monique J. ;

Schroder, Fritz H. ;

Tammela, Teuvo L. J. ;

Aus, Gunnar ;

Auvinen, Anssi P. ;

Hugosson, Jonas .

BJU INTERNATIONAL, 2011, 107 (12) :1912-1917

[5] Mortality at 120 days after prostatic biopsy:: A population-based study of 22,175 men [J].

Gallina, Andrea ;

Suardi, Nazareno ;

Montorsi, Francesco ;

Capitanio, Umberto ;

Jeldres, Claudio ;

Saad, Fred ;

Graefen, Markus ;

Shariat, Shahrokh F. ;

Widmer, Hugues ;

Arjane, Philippe ;

Peloquin, Francois ;

Perrotte, Paul ;

Karakiewicz, Pierre I. .

INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (03) :647-652

[6] Infectious Complications and Hospital Admissions After Prostate Biopsy in a European Randomized Trial [J].

Loeb, Stacy ;

van den Heuvel, Suzanne ;

Zhu, Xiaoye ;

Bangma, Chris H. ;

Schroder, Fritz H. ;

Roobol, Monique J. .

EUROPEAN UROLOGY, 2012, 61 (06) :1110-1114

[7] Complications After Prostate Biopsy: Data From SEER-Medicare [J].

Loeb, Stacy ;

Carter, H. Ballentine ;

Berndt, Sonja I. ;

Ricker, Winnie ;

Schaeffer, Edward M. .

JOURNAL OF UROLOGY, 2011, 186 (05) :1830-1834

[8]

Nam RK, 2010, J UROLOGY, V183, P936

[9] Complications following prostate needle biopsy requiring hospital admission or emergency department visits - experience from 1000 consecutive cases [J].

Pinkhasov, G. Igor ;

Lin, Yu-Kuan ;

Palmerola, Ricardo ;

Smith, Paul ;

Mahon, Frank ;

Kaag, Matthew G. ;

Dagen, J. Edward ;

Harpster, Lewis E. ;

Reese, Carl T. ;

Raman, Jay D. .

BJU INTERNATIONAL, 2012, 110 (03) :369-374

[10] Evidence of a healthy volunteer effect in the prostate, lung, colorectal, and ovarian cancer screening trial [J].

Pinsky, P. F. ;

Miller, A. ;

Kramer, B. S. ;

Church, T. ;

Reding, D. ;

Prorok, P. ;

Gelmann, E. ;

Schoen, R. E. ;

Buys, S. ;

Hayes, R. B. ;

Berg, C. D. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 165 (08) :874-881

← 1 2 →