Randainins A-D, Based on Unique Diterpenoid Architectures, from Callicarpa randaiensis

被引：16

作者：

Cheng, Ho-Hsi ^{[1
]}

Cheng, Yuan-Bin ^{[2
]}

Hwang, Tsong-Long ^{[3
,4
,5
,6
,7
]}

Kuo, Yao-Haur ^{[8
]}

Chen, Chung-Hsiung ^{[1
]}

Shen, Ya-Ching ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 100, Taiwan

[2] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[3] Chang Gung Univ, Coll Med, Sch Tradit Med, Grad Inst Nat Prod, Taoyuan 33302, Taiwan

[4] Chang Gung Univ, Hlth Aging Res Ctr, Chinese Herbal Med Res Team, Grad Inst Nat Prod, Taoyuan 33302, Taiwan

[5] Chang Gung Univ Sci & Technol, Dept Cosmet Sci, Taoyuan 33302, Taiwan

[6] Chang Gung Univ Sci & Technol, Res Ctr Ind Human Ecol, Taoyuan 33302, Taiwan

[7] Chang Gung Mem Hosp, Immunol Consortium, Taoyuan 33302, Taiwan

[8] Natl Res Inst Chinese Med, Div Herbal Drugs & Nat Prod, Taipei 112, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 08期

关键词：

ABIETANE DITERPENOIDS; CONSTITUENTS; LEAVES; NEUTROPHILS; TERPENOIDS; AMERICANA;

D O I：

10.1021/acs.jnatprod.5b00012

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new compounds, randainins A-D (1-4), were isolated from the leaves and twigs of Callicarpa randaiensis, which is an endemic species in Taiwan. Compounds 1 and 2 are diterpenoids with an unusual trans-7/5 ring system, whereas compounds 3 and 4 are diterpenoids possessing a trans-5/7 ring scaffold. The structures of the new compounds were established based on NMR and MS data analyses. Anti-inflammatory activities and cytotoxicity were tested and evaluated for these compounds. Compound 4 exhibited moderate inhibition of superoxide-anion generation with an IC50 value of 21.5 +/- 2.5 mu M.

引用

页码：1823 / 1828

页数：6

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