Cerebral perfusion alterations in patients with trigeminal neuralgia as measured by pseudo-continuous arterial spin labeling

被引：2
作者：
Zhou, Qianling [1 ,2 ]
Li, Meng [2 ]
Fan, Qisen [3 ]
Chen, Feng [2 ]
Jiang, Guihua [2 ]
Wang, Tianyue [2 ]
He, Qinmeng [2 ]
Fu, Shishun [2 ]
Yin, Yi [2 ]
Lin, Jinzhi [4 ]
Yan, Jianhao [1 ,2 ]
机构：
[1] Southern Med Univ, Sch Clin Med 2, Guangzhou, Peoples R China
[2] Guangdong Second Prov Gen Hosp, Dept Med Imaging, Guangzhou, Peoples R China
[3] Guangzhou Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Guangzhou, Peoples R China
[4] Guangdong Second Prov Gen Hosp, Dept Neurosurg, Guangzhou, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2022年 / 16卷
关键词：
trigeminal neuralgia; chronic pain; arterial spin labeling; cerebral blood flow; functional MRI; brain; DORSOLATERAL PREFRONTAL CORTEX; LOW-BACK-PAIN; FUNCTIONAL CONNECTIVITY; PREVALENCE; SYSTEM; IMPACT;
D O I：
10.3389/fnins.2022.1065411
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
BackgroundAccumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in patients with TN and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN. Materials and methodsThis study included 28 patients with TN and 30 age- and sex-matched healthy controls (HCs) who underwent perfusion functional MRI (fMRI) of the brain using pseudo-continuous arterial spin labeling (pCASL) in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Then, the relationships between the clinical characteristics and abnormal rCBF were further investigated. ResultsCompared to the control group, patients with TN exhibited increased rCBF, primarily in the thalamus, middle frontal gyrus (MFG), and left insula. Furthermore, the CBF values of the thalamus were negatively correlated with the pain intensity of TN and positively correlated with pain duration in patients with TN. ConclusionPrimary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding the neuropathological mechanism underlying TN.
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页数：10
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