Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin

被引：201

作者：

Choi, Jae Sue ^{[1
]}

Islam, Md. Nurul ^{[1
]}

Ali, Md. Yousof ^{[1
]}

Kim, Eon Ji ^{[1
]}

Kim, Young Myeong ^{[2
]}

Jung, Hyun Ah ^{[3
]}

机构：

[1] Pukyong Natl Univ, Dept Food Sci & Nutr, Pusan 608737, South Korea

[2] Kangwon Natl Univ, Sch Med, Dept Mol & Cellular Biochem, Chunchon 200701, South Korea

[3] Chonbuk Natl Univ, Dept Food Sci & Human Nutr, Jeonju 561756, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 64卷

基金：

新加坡国家研究基金会;

关键词：

Flavonoid; Apigenin derivative; Diabetic complication; Alzheimer's disease; Inflammation; PHOSPHATASE 1B INHIBITORS; GLYCATION END-PRODUCTS; NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; PROTEIN; PATHOGENESIS; ISOVITEXIN; FLAVONE; ACID;

D O I：

10.1016/j.fct.2013.11.020

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Apigenin has gained particular interests in recent years as a beneficial and health promoting agent because of its low intrinsic toxicity. Vitexin and isovitexin, naturally occurring C-glycosylated derivatives of apigenin, have been known to possess potent anti-diabetic, anti-Alzheimer's disease (anti-AD), and anti-inflammatory activities. The present study was designed to investigate the anti-diabetic, anti-AD, and anti-inflammatory potential of apigenin and its two C-glycosylated derivatives, vitexin and isovitexin by in vitro assays including rat lens aldose reductase (RLAR), human recombinant aldose reductase (HRAR), advanced glycation endproducts (AGEs), protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), beta-site amyloid precursor (APP) cleaving enzyme 1 (BACE1), and nitric oxide (NO), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Among them, isovitexin was found as the most potent inhibitor against RLAR, HRAR, AGE, AChE, and BChE while vitexin showed the most potent PTP1B inhibitory activity. Despite the relatively weak anti-diabetic and anti-AD potentials, apigenin showed powerful antiinflammatory activity by inhibiting NO production and iNOS and COX-2 expression while vitexin and isovitexin were inactive. Therefore, it could be speculated that C-glycosylation of apigenin at different positions might be closely linked to relative intensity of anti-diabetic, anti-AD, and antiinflammatory potentials. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：27 / 33

页数：7

共 41 条

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