A Systems Approach to Analysis of Molecular Complexity in Breast Cancer

被引：11

作者：

Hennessy, Bryan T. ^{[1
]}

Gonzalez-Angulo, Ana Maria

Carey, Mark S.

Mills, Gordon B.

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA

来源：

CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 02期

关键词：

OVARIAN; AMPLIFICATION; RESISTANCE; ONCOGENE;

D O I：

10.1158/1078-0432.CCR-08-2620

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Clinical Cancer Research, Andre et al, apply high-resolution arrays to elucidate copy number anomalies in breast cancer. They identify distinct copy number anomaly patterns in different breast cancer subtypes that implicate a number of genes as potential therapeutic targets and as potential markers of therapy responsiveness.

引用

页码：417 / 419

页数：3

共 12 条

[1]

ANDRE F, 2009, CLIN CANC R IN PRESS, P15

[2]

Bautista S, 1998, CLIN CANCER RES, V4, P2925

[3] MOLECULAR ALTERATIONS OF THE AKT2 ONCOGENE IN OVARIAN AND BREAST CARCINOMAS [J].

BELLACOSA, A ;

DEFEO, D ;

GODWIN, AK ;

BELL, DW ;

CHENG, JQ ;

ALTOMARE, DA ;

WAN, MH ;

DUBEAU, L ;

SCAMBIA, G ;

MASCIULLO, V ;

FERRANDINA, G ;

PANICI, PB ;

MANCUSO, S ;

NERI, G ;

TESTA, JR .

INTERNATIONAL JOURNAL OF CANCER, 1995, 64 (04) :280-285

[4] Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer [J].

Bergamaschi, Anna ;

Kim, Young H. ;

Wang, Pei ;

Sorlie, Therese ;

Hernandez-Boussard, Tina ;

Lonning, Per E. ;

Tibshirani, Robert ;

Borresen-Dale, Anne-Lise ;

Pollack, Jonathan R. .

GENES CHROMOSOMES & CANCER, 2006, 45 (11) :1033-1040

[5] A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer [J].

Berns, Katrien ;

Horlings, Hugo M. ;

Hennessy, Bryan T. ;

Madiredjo, Mandy ;

Hijmans, E. Marielle ;

Beelen, Karin ;

Linn, Sabine C. ;

Gonzalez-Angulo, Ana Maria ;

Stemke-Hale, Katherine ;

Hauptmann, Michael ;

Beijersbergen, Roderick L. ;

Mills, Gordon B. ;

de Vijver, Marc J. van ;

Bernards, Rene .

CANCER CELL, 2007, 12 (04) :395-402

[6] Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer [J].

Bostner, J. ;

Waltersson, M. Ahnstrom ;

Fornander, T. ;

Skoog, L. ;

Nordenskjold, B. ;

Stal, O. .

ONCOGENE, 2007, 26 (49) :6997-7005

[7] The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers [J].

Cheng, KW ;

Lahad, JP ;

Kuo, WL ;

Lapuk, A ;

Yamada, K ;

Auersperg, N ;

Liu, JS ;

Smith-McCune, K ;

Lu, KH ;

Fishman, D ;

Gray, JW ;

Mills, GB .

NATURE MEDICINE, 2004, 10 (11) :1251-1256

[8] Genomic and transcriptional aberrations linked to breast cancer pathophysiologies [J].

Chin, Koei ;

DeVries, Sandy ;

Fridlyand, Jane ;

Spellman, Paul T. ;

Roydasgupta, Ritu ;

Kuo, Wen-Lin ;

Lapuk, Anna ;

Neve, Richard M. ;

Qian, Zuwei ;

Ryder, Tom ;

Chen, Fanqing ;

Feiler, Heidi ;

Tokuyasu, Taku ;

Kingsley, Chris ;

Dairkee, Shanaz ;

Meng, Zhenhang ;

Chew, Karen ;

Pinkel, Daniel ;

Jain, Ajay ;

Ljung, Britt Marie ;

Esserman, Laura ;

Albertson, Donna G. ;

Waldman, Frederic M. ;

Gray, Joe W. .

CANCER CELL, 2006, 10 (06) :529-541

[9] Comprehensive genomic characterization defines human glioblastoma genes and core pathways [J].

Chin, L. ;

Meyerson, M. ;

Aldape, K. ;

Bigner, D. ;

Mikkelsen, T. ;

VandenBerg, S. ;

Kahn, A. ;

Penny, R. ;

Ferguson, M. L. ;

Gerhard, D. S. ;

Getz, G. ;

Brennan, C. ;

Taylor, B. S. ;

Winckler, W. ;

Park, P. ;

Ladanyi, M. ;

Hoadley, K. A. ;

Verhaak, R. G. W. ;

Hayes, D. N. ;

Spellman, Paul T. ;

Absher, D. ;

Weir, B. A. ;

Ding, L. ;

Wheeler, D. ;

Lawrence, M. S. ;

Cibulskis, K. ;

Mardis, E. ;

Zhang, Jinghui ;

Wilson, R. K. ;

Donehower, L. ;

Wheeler, D. A. ;

Purdom, E. ;

Wallis, J. ;

Laird, P. W. ;

Herman, J. G. ;

Schuebel, K. E. ;

Weisenberger, D. J. ;

Baylin, S. B. ;

Schultz, N. ;

Yao, Jun ;

Wiedemeyer, R. ;

Weinstein, J. ;

Sander, C. ;

Gibbs, R. A. ;

Gray, J. ;

Kucherlapati, R. ;

Lander, E. S. ;

Myers, R. M. ;

Perou, C. M. ;

McLendon, Roger .

NATURE, 2008, 455 (7216) :1061-1068

[10] EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer [J].

Hughes-Davies, L ;

Huntsman, D ;

Ruas, M ;

Fuks, F ;

Bye, J ;

Chin, SF ;

Milner, J ;

Brown, LA ;

Hsu, F ;

Gilks, B ;

Nielsen, T ;

Schulzer, M ;

Chia, S ;

Ragaz, J ;

Cahn, A ;

Linger, L ;

Ozdag, H ;

Cattaneo, E ;

Jordanova, ES ;

Schuuring, E ;

Yu, DS ;

Venkitaraman, A ;

Ponder, B ;

Doherty, A ;

Aparicio, S ;

Bentley, D ;

Theillet, C ;

Ponting, CP ;

Caldas, C ;

Kouzarides, T .

CELL, 2003, 115 (05) :523-535

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